Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes



Status:Active, not recruiting
Conditions:Obesity Weight Loss, Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:25 - 65
Updated:8/11/2018
Start Date:August 2014
End Date:September 2019

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Trial Summary
Trial Overview
Inclusion Criteria
For this purpose, we will compare the effects of 16-18% weight loss induced by Roux-en-Y
Gastric bypass (RYGB) surgery or sleeve gastrectomy (SG) surgery with the same weight loss
induced by a low-calorie diet (LCD) on liver and skeletal muscle insulin sensitivity,
beta-cell function, and 24-hour metabolic homeostasis in obese subjects with T2D.


Inclusion Criteria:

RYGB/SG

- Scheduled for one of these bariatric surgeries

- Body Mass Index (BMI) 35-55 kg/m²

- Type 2 Diabetes

- Signed informed consent

Low-Calorie Diet

- BMI 35-55 kg/m²

- Type 2 Diabetes and Non-Diabetics

- Signed informed consent

Exclusion Criteria:

RYGB/SG & Low-Calorie Diet

- Regular use of tobacco products

- Previous intestinal resection

- Pregnant or breastfeeding

- Evidence of significant organ system dysfunction or disease other than T2D

- Use of any medication that might, in the opinion of the investigator, affect metabolic
function

- Exercise ≥90 minutes per week
We found this trial at
1
site
Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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mi
from
Saint Louis, MO
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