Dose Escalation Trial of Endoluminal High-Dose-Rate Brachytherapy With Concurrent Chemotherapy for Rectal or Anal Cancer in Patients With Recurrent Disease or Undergoing Non-Operative Management



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:3/27/2019
Start Date:July 2014
End Date:July 2020
Contact:Abraham Wu, MD
Phone:212-639-5257

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A Phase I, Dose Escalation Trial of Endoluminal High Dose Rate Brachytherapy With Concurrent Chemotherapy for Rectal or Anal Cancer in Patients With Recurrent Disease or Undergoing Non-Operative Management

The purpose of this study is to see what amount of radiation is safe to give to rectal or
anal cancer patients who are being treated with a procedure called brachytherapy.


Inclusion Criteria:

- Histologically or cytologically confirmed locally residual or recurrent cancer of the
rectum or anus

- Prior pelvic EBRT

- Age > or = to 18 years

- ECOG performance status 0, 1, or 2

- At least 4 weeks from prior major surgery or radiotherapy

- Have undergone Surgical, Medical and Radiation Oncology evaluations to confirm :

- Eligible for infusional 5-FU or capecitabine

- Will not undergo surgery for the study disease

- Able to receive HDR brachytherapy ANC ≥ 1.5 cells/mm3 and PLT ≥100,000/mm3

- Adequate Renal function: Creatinine <1.5 x the upper limit of normal (ULN) or
calculated creatinine clearance of ≥ 50cc/min

- Adequate Hepatic functions: Bilirubin less than 1.5 mg/dL; (except in patients with
Gilbert's Syndrome, who must have a total bilirubin less than 3.0 mg/dL)

- AST or ALT <3xULN, or <5x ULN if known liver metastases

- Normal Cardiac function:

- No active coronary artery disease;

- No New York Heart Association class II, III or IV disease;

- No arrhythmia requiring treatment

- Maximum tumor length of 7 cm at time of brachytherapy treatment start

Exclusion Criteria:

- Women who are pregnant.

- Women of childbearing potential who are unwilling or unable to use an acceptable
method to avoid pregnancy for the entire treatment period and after receipt of
brachytherapy. Male subjects must also agree to use effective contraception during the
treatment period and until 1 year after the completion of brachytherapy.

- Patients with any other concurrent medical or psychiatric condition or disease which,
in the investigator's judgment, would make them inappropriate candidates for entry
into this study.

- Patients on concurrent anti-cancer therapy other than that allowed in the study.

- Contraindications to general anesthesia
We found this trial at
7
sites
1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 212-639-5257
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Basking Ridge, New Jersey 07920
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Commack, New York 11725
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Harrison, New York 10604
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Middletown, New Jersey 07748
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Rockville Centre, New York 11570
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Uniondale, New York 11553
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