The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)

Therapuetic Areas:Psychiatry / Psychology
Age Range:18 - Any
Start Date:April 2015
End Date:June 2019
Contact:Liz Doohan, BA

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The investigators are conducting a randomized clinical trial of rapid abstinence initiation
and cognitive control training as a precursor to our new web-based version of the CBT4CBT
(Computer Based Training for Cognitive Behavioral Therapy) program to evaluate its
effectiveness relative to standard outpatient counseling at the Midwestern Connecticut
Council of Alcoholism (MCCA). CCT will be used to assess attention, working memory and
inhibitory control and the computer-based training program (CBT4CBT) focuses on teaching
basic coping skills, presenting examples of effective use of coping skills in a number of
realistic situations in video form, and providing opportunities for patients to practice and
review new skills while receiving cocaine abuse treatment.

150 cocaine dependent individuals will be randomly assigned to one of 3 conditions delivered
over 4 weeks in the context of intensive outpatient treatment. 1. Treatment as Usual (TAU),
2. rapid abstinence initiation (RAI) or 3. computerized cognitive control training with
escalating reinforcement for improved performance on training tasks (CCT). All participants
will then receive an 8 week trial of CBT4CBT in addition to TAU. Follow up evaluation thru 6
months posttreatment will assess durability and delayed emergence of treatment effects.

Inclusion Criteria:

- 18 years of age or older

- Meet current DSM-5 criteria for cocaine use disorder

- Are sufficiently stable for 12 weeks of outpatient treatment

- Are willing to provide locator information for follow-up

- Are fluent in English

- Have a 6th grade or higher reading level for completion of assessments

Exclusion Criteria:

- Untreated bipolar or schizophrenic disorder

- Current suicide risk

- Have a legal case pending such that incarceration during the 12-week protocol is

- Are physically dependent on alcohol, opioids or benzodiazepines and require
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New haven, Connecticut 06511
New haven, CT
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140 John Street
Bridgeport, Connecticut 06601
Bridgeport, CT
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