An Efficacy and Safety Study of Simeprevir and Sofosbuvir With and Without Ribavirin in Participants With Recurrent Genotype 1 Hepatitis C Post-Orthotopic Liver Transplant

This is a Phase 2, multicenter (when more than one hospital or medical school team work on a
medical research study), partially randomized (study drug is assigned by chance), and
open-label (all people know the identity of the intervention) study to explore the safety
and efficacy of simeprevir plus sofosbuvir. The study will consist of a screening period
(Screening and Baseline), followed by randomization. First 33 non-cirrhotic participants
will be randomly assigned in a ratio of 1:1:1 into 1 of 3 treatment arms, and up to 12
cirrhotic participants will be enrolled and all will be assigned to Arm 3. All participants
in treatment Arms 1 and 2 will return for treatment visits at Weeks 1, 2, 4, 8, 12, and
post-treatment follow-up visits on Weeks 16 and 24. All participants in treatment Arm 3 will
return for treatment visits at Weeks 1, 2, 4, 8, 12, 16, 20, and 24, and post-treatment
follow-up visits on Weeks 28 and 36. Participants will receive simeprevir plus sofosbuvir
and RBV for a 12-week treatment period in Arm 1, simeprevir plus sofosbuvir without RBV for
a 12-week treatment period in Arm 2 and simeprevir plus sofosbuvir for a 24-week treatment
period in Arm 3. Efficacy will primarily be evaluated by SVR12. Participants' safety will be
monitored throughout the study.

Inclusion Criteria:

- Participant must be infected with Hepatitis C virus (HCV) Genotype 1 (1a or 1b) with
Baseline HCV ribonucleic acid (RNA) greater than (>) 10,000 international unit per
milliliter (IU/mL). Retesting of HCV RNA to assess eligibility will be allowed once,
using an unscheduled visit during the Screening period

- Participant must have had an orthotopic liver transplant greater than or equal to
(>=) 6 months to 15 years prior to enrollment

- Participant must have had primary liver transplant

- Participant must be on a stable immunosuppressive regimen for at least 3 months prior
to the Screening visit. Immunosuppression regimens may include calcineurin inhibitors
(for example, tacrolimus), mammalian target of rapamycin (mTOR) inhibitor,
mycophenolate mofetil, prednisone, prednisolone less than or equal to (<=) 5
milligram per day (mg/day), other corticosteroids (except systemic dexamethasone),
sirolimus, everolimus, or azathioprine. Stable immunosuppression includes normal
adjustment of immunosuppressant dose but excludes changes in immunosuppressant
medication and/or treatment of rejection.

- Participant's renal function as measured by the Cockcroft Gault formula must be >30
milliliter per minute (mL/min)

Exclusion Criteria:

- Participants received prior treatment with an investigational or Food and Drug
Administration (FDA) approved direct-acting antiviral drug for the treatment of
hepatitis C. Prior HCV treatment with interferon or peginterferon with or without
ribavirin (RBV) is allowed but must have been completed at least 3 months prior to
Screening

- Participants with hepatic decompensation defined by any of the following: 1) Any
post-liver transplant clinical signs including ascites, hepatic encephalopathy,
and/or evidence of varices with or without variceal bleeding, and 2)
Child-Turcotte-Pugh (CTP) score >=7

- Participant has (post-transplant) any underlying serious or life-threatening
condition, such as severe uncontrolled cardiopulmonary disease, vascular disease,
rheumatologic condition, renal failure, dialysis, ongoing systemic infection,
uncontrolled malignancy, or other serious illness that would compromise adherence to
medications and ability to comply with all aspects of the study protocol

- Any other active, clinically significant disease or clinically significant findings
during the Screening period of medical history, physical examination, laboratory
testing, or electrocardiogram (ECG) recording that, in the investigator's opinion,
would compromise the participant's safety or could interfere with the participant
participating in and completing the study. Retesting of laboratory results that lead
to exclusion will be allowed once using an unscheduled visit during the Screening
period to assess eligibility

- Participant is a woman who is pregnant, breast-feeding, or planning to become
pregnant while enrolled in this study or within 6 months after the last dose of
ribavirin (or longer when dictated by local regulations)