3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | June 24, 2014 |
| End Date: | June 2019 |
| Contact: | Johanna Kim, MPH |
| Email: | johanna.kim@cshs.org |
| Phone: | 310 248-8680 |
This is a technical development study with the goal to develop 3D techniques for
atherosclerosis plaque characterization. We hypothesize that 3D MRI is superior to 2D MRI in
characterizing major plaque constituents that contribute to severe clinical events such as
myocardial infarction or stroke. The major advantages of the 3D techniques to be developed
will include high spatial resolution, reduced scan times, and optimized image contrast. The
use of contrast injection is not needed with the new techniques, which is greatly beneficial
for patients with advanced chronic kidney disease.This is not a funded clinical trial.
atherosclerosis plaque characterization. We hypothesize that 3D MRI is superior to 2D MRI in
characterizing major plaque constituents that contribute to severe clinical events such as
myocardial infarction or stroke. The major advantages of the 3D techniques to be developed
will include high spatial resolution, reduced scan times, and optimized image contrast. The
use of contrast injection is not needed with the new techniques, which is greatly beneficial
for patients with advanced chronic kidney disease.This is not a funded clinical trial.
All participants will undergo the conventional MRI protocol and the new imaging protocol
using our developed techniques. They may have either non-contrast scans or contrast-enhanced
scans or both depending on the stage of development. The comparison results between the two
protocols will be used to evaluate the performance of the new techniques and help
optimization of specific technical aspects.
using our developed techniques. They may have either non-contrast scans or contrast-enhanced
scans or both depending on the stage of development. The comparison results between the two
protocols will be used to evaluate the performance of the new techniques and help
optimization of specific technical aspects.
Inclusion Criteria:
- Healthy Volunteers: male or female ≥ 18 years of age with a BMI<30, with no history of
cardiovascular disease
- Patients: Medically stable, male or female ≥ 18 years of age diagnosed with an
atherosclerotic plaque in the carotid artery who have not undergone stenting of the
carotid artery to be imaged.
- Ability to read and understand informed consent
Exclusion Criteria:
- Contraindications to MRI including mechanically, magnetically, or electrically
activated implants, ferromagnetic implants and ferromagnetic foreign bodies,
pregnancy.
- Inability to tolerate MRI secondary to an inability to lie supine or severe
claustrophobia.
- Non-compliant with visit instructions, including inability to lie still, hold breath
or follow procedure instructions
- Severe allergy to animal dander or animal-instigated asthma
- Specific to gadolinium-based contrast agents: Renal function test does not meet CSMC
standard of care MRI contrast protocol requirements (GFR <45ml/min) or previous
allergic reaction to gadolinium-based contrast agents.*
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