Salivary Cortisol Measurements by Mass Spectrometry
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 3 - 17 |
| Updated: | 4/2/2016 |
| Start Date: | June 2013 |
| End Date: | June 2025 |
Pilot Study of Salivary Cortisol Measurements by Mass Spectrometry
Cortisol is a hormone critical for survival in times of stress. Currently most measurements
are done with blood samples. The hypothesis of this study is cortisol measured from saliva
using mass spectrometry can be used to replace measurements by blood.
are done with blood samples. The hypothesis of this study is cortisol measured from saliva
using mass spectrometry can be used to replace measurements by blood.
Cortisol levels change depending on the time of day. Salivary samples were collected from
health controls at bedtime, midnight and first morning waking on two consecutive nights and
salivary cortisol levels were measured using mass spectrometry. In a patients with possible
endocrine disorders who were going through an adrenocortiotropin stimulation test for
adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40
minutes after cosyntropin.
health controls at bedtime, midnight and first morning waking on two consecutive nights and
salivary cortisol levels were measured using mass spectrometry. In a patients with possible
endocrine disorders who were going through an adrenocortiotropin stimulation test for
adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40
minutes after cosyntropin.
Inclusion Criteria:
- Normal subjects
- Subjects with possible endocrine disorder
Exclusion Criteria:
- Tracheostomy or ventilator dependent
- Gastrotomy tubed dependent or unable to eat/drink by mouth
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