CD34+ Cell Enriched and T Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Mismatched Related Donors or Borderline Organ Function

Inclusion Criteria:

- Participant age is 0 (newborn) to 35 years-old.

- Participant has a disorder affecting the hematopoietic system that are inherited,
acquired, or a result from the myeloablative treatment that can benefit from
alternative stem cell transplantation according to standard practice guidelines for
including patients for transplant.

- Participant's medical screening clears s/he for allogeneic transplantation as per
current institutional SOP based on standards of foundation for accreditation of
cellular therapy and stem cell transplantation (FACT);

- Participant must lack a healthy, HLA-identical related or unrelated donor unless s/he
has a borderline organ function that will preclude the recipient from receiving a
curative therapy due to the need of post-HSCT immunosuppressive therapy.

- Participant must have a matched or mismatched-related donor who is:

- Able to receive granulocyte colony-stimulating factor (G-CSF) and undergo apheresis
either through placement of catheters in antecubital veins or a temporary central
venous catheter OR agrees on a bone marrow harvest;

- Healthy as per donor selection screening (following current SOP based on standards of
foundation for accreditation of cellular therapy and stem cell transplantation -
FACT);

- Willing to participate and sign consent.

- Participant or Legal Authorized Representative is able to sign informed consent (and
signed assent, if applicable) for transplant.

Exclusion Criteria:

- Participant does not qualify for an allogeneic transplant due to medical screening,
underlying disease, or lack of alternative donors.

- Any condition that compromises compliance with the procedures of this protocol, as
judged by the principal investigator.