Effects of Reducing Indoor Air Pollution on the Adult Asthmatic Response



Status:Recruiting
Conditions:Asthma
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 50
Updated:12/9/2018
Start Date:February 2014
End Date:February 2019
Contact:Kim Ladson, CO MA
Email:kladson1@jhmi.edu
Phone:410-550-2708

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This study is about asthma and how the environment affects asthma. Scientists know that air
pollution (such as cigarette smoke and other particles in the air) can make asthma symptoms
worse. This research is being done to study how the health of a person with asthma responds
to an air cleaner. The investigator hypothesize that an air cleaner will improve the health
of persons with asthma.

The investigators seek to determine the effect of placing air cleaner devices in the homes of
adults with asthma on their asthma health. To this end, the investigators aim to study 40
adults with asthma that are 18-50 years of age and live in Baltimore. They will receive
either true air cleaners or sham cleaners in a blinded, randomized manner for one month, and
then, after a washout period, they will cross over and receive the other intervention (sham
or true cleaner). All participants will have environmental monitoring (personal and in-home)
to determine their particulate matter exposure, and be followed repeatedly during the 3 month
study period for markers of asthma disease, including respiratory symptoms, medication and
health care utilization, pulmonary function, airway hyperresponsiveness, systemic markers of
inflammation, and bronchoscopic evidence of airway inflammation or epithelial cell
dysfunction. Modifying factors or factors influencing susceptibility, such as diet and
nutritional status, will also be explored.

Inclusion Criteria:

- Age 18-50 years of age

- Non-smoker (<100 cigarettes in lifetime)

- Physician diagnosis of asthma

- Symptoms of asthma and/or reliever medication use in the past 6 months

- Living in the current residence >= 6 months within Baltimore

- Enrollment in, and completion of, the observational environmental asthma study "Inhale
1"

Exclusion Criteria:

- Current diagnosis of another major pulmonary disease, other significant morbidity

- Pregnancy (as defined by a positive urine pregnancy test at screening of all women of
child-bearing potential)

- Planning to relocate residence or activity that necessitates travel away from home for
prolonged period of time during the study period

- Current use of an air cleaner in the home
We found this trial at
2
sites
1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Principal Investigator: Sonali Bose, MD MPH
Phone: 410-550-2708
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
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4940 Eastern Ave
Baltimore, Maryland 21224
(410) 550-0100
Principal Investigator: Sonali Bose, MD MPH
Phone: 410-550-2708
Johns Hopkins Bayview Medical Center There is no better story in American medicine in the...
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