Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy

Therapuetic Areas:Neurology
Age Range:18 - 60
Start Date:May 2014
End Date:May 2021

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LIFUP for Treatment of Temporal Lobe Epilepsy

We intend to use focused ultrasound to stimulate or suppress brain activity in patients with
epilepsy. We hypothesize that focused ultrasound is capable of brain stimulation or
suppression visible with functional MRI, and will not cause tissue damage.

Inclusion Criteria:

- Subjects with clinical evidence from their diagnostic evaluations of unilateral
hippocampal dysfunction and epileptogenicity.

- Subjects with seizures that have been refractory to treatment with at least three
currently marketed antiepileptic drugs.

- Subjects with epilepsy who would clearly benefit from surgical intervention.

- Subjects who have been offered a non-dominant anterior-mesial temporal lobe resection
as treatment for medication refractory epilepsy.

Exclusion Criteria:

- Subjects with a cognitive or psychiatric disorder that limits the ability to give
informed consent or are unable to cooperate with the testing.

- Subjects with dementia, delirium and psychotic symptoms. - Subjects with ferromagnetic
materials in the head.

- Subjects with severe cardiac disease, increased intracranial pressure, or a TENS unit.

- Subjects who exhibit primary generalized seizures or pseudoseizures.

- Subjects who have seizures secondary to drugs, alcohol, metabolic illness or
progressive degenerative disease.

- Subjects who have experienced status epilepticus during the 3-week baseline period
prior to the operation.

- Subjects (females) who are pregnant.
We found this trial at
Los Angeles, California 90095
(310) 825-4321
Principal Investigator: John Stern, MD
Phone: 323-510-7532
UCLA UCLA's primary purpose as a public research university is the creation, dissemination, preservation and...
Los Angeles, CA
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