Stress and Sugar Synergy
| Status: | Completed |
|---|---|
| Conditions: | High Cholesterol, Endocrine, Endocrine |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 25 - 40 |
| Updated: | 1/18/2019 |
| Start Date: | April 2014 |
| End Date: | December 2016 |
Synergistic Effects of Stress and Sugar Feeding on Metabolism
The main objectives of this study are to test the hypotheses that: 1) consumption of
beverages sweetened with sucrose will increase risk factors for cardiovascular disease to a
greater extent than a naturally-sweetened fruit juice such as orange juice, and 2) chronic
psychological stress may augment the adverse metabolic effects of sugar intake. The study
intervention consists of 2-week's consumption of 25% of energy as sugar provided either as a
sucrose-sweetened beverage or naturally-sweetened orange juice.
beverages sweetened with sucrose will increase risk factors for cardiovascular disease to a
greater extent than a naturally-sweetened fruit juice such as orange juice, and 2) chronic
psychological stress may augment the adverse metabolic effects of sugar intake. The study
intervention consists of 2-week's consumption of 25% of energy as sugar provided either as a
sucrose-sweetened beverage or naturally-sweetened orange juice.
Inclusion Criteria:
- Body mass index between 28-35
- Self report of stable body weight during the past six months
- High stress participants: Perceived Stress Scores (PSS) ≥ 24, and the presence of a
predefined chronically stressful event as assessed by the Telephone screening
questions. (IDS scores are not an inclusion criteria in this group, merely a rule-out
for the low stress participants).
- Low stress participants: PSS scores ≤ 8, Inventory for Depressive Symptom (IDS) scores
≤ 14, and the absence of any predefined chronically stressful events as assessed by
the telephone screening questions.
Exclusion Criteria:
- glucose intolerance
- Evidence of liver disorder
- Evidence of kidney disorder
- Evidence of thyroid disorder
- Systolic blood pressure consistently over 140mmHg or diastolic blood pressure over
90mmHg
- Triglycerides > 200mg/dl
- LDL-C > 130mg/dl
- Hemoglobin < 8.5 g/dl
- pregnant or lactating women
- Current, prior (within 12 months), or anticipated use of any hypolipidemic or
anti-diabetic agents
- Use of Selective Serotonin Reuptake Inhibitors and anti-hypertensive medications
- Any other condition that, in the opinion of the investigators, would put subject at
risk
- Strenuous exerciser
- surgery for weight loss
- Diet exclusions: food allergies, special dietary restrictions, habitual ingest of >2
alcoholic beverages/day
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