IMPAACT P1107: Effects of Cord Blood Transplantation With CCR5Δ32 Donor Cells on HIV Persistence



Status:Recruiting
Conditions:HIV / AIDS, HIV / AIDS
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:7/28/2018
Start Date:February 2015
End Date:March 2023
Contact:Anne Coletti, MS
Email:acoletti@fhi360.org
Phone:919-544-7040

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IMPAACT P1107: Cord Blood Transplantation With CCR5Δ32 Donor Cells in HIV-1 Infected Subjects Who Require Bone Marrow Transplantation for Any Indication and Its Observed Effects on HIV-1 Persistence

IMPAACT P1107 will describe the outcomes of HIV-infected persons, ages 12 months and older,
who undergo transplantation with CCR5Δ32 cord blood stem cells for treatment of cancer,
hematopoietic disease, or other underlying disease.


Inclusion Criteria:

- Confirmed HIV-1 infection

- 12 months of age or older

- Willing to provide written informed consent

- Pre-Transplant Cohort: Underlying disease appropriate for stem cell transplant, as
determined by the transplant team as part of standard of care.

- Pre-Transplant Cohort: Availability of an appropriately matched (as determined by the
transplant center) CCR5Δ32 cord blood unit (homozygous or heterozygous) and intention
to proceed with transplantation. NOTE: Double cord transplants are allowed. If a
double cord is used, at least one cord blood unit should be CCR5∆32 (homozygous or
heterozygous).

- Pre-Transplant Cohort: Received a CCR5Δ32 homozygous cord blood or bone marrow
transplant within the last two years.

Exclusion Criteria:

• Received, or planning to receive, more than one CCR5Δ32 homozygous cord blood or bone
marrow transplant.
We found this trial at
2
sites
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Rachel Presti, MD, PhD
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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New York, New York
Principal Investigator: Koen van Besien, MD
Phone: 212-746-7134
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New York, NY
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