Bone Health in Youth With Type 1 Diabetes



Status:Active, not recruiting
Conditions:Osteoporosis, Diabetes, Diabetes
Therapuetic Areas:Endocrinology, Rheumatology
Healthy:No
Age Range:10 - 16
Updated:1/6/2019
Start Date:August 2013
End Date:July 2020

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Trial Summary
Trial Overview
Inclusion Criteria

Bone Mineral Accrual and Microarchitecture in Youth With Type 1 Diabetes

This is an observation study of girls ages 10-16 years with type 1 diabetes and age- and
race-matched controls. The investigators will be examining blood and urine hormone levels as
well as measures of bone density including DXA and high-resolution peripheral quantitiative
computed tomography. The investigators hypothesize that youth with type 1 diabetes will have
slower bone accrual and impaired bone microarchitectural integrity compared with non-diabetic
controls. The investigators hypothesize that poor bone accrual will be associated with
sub-optimal glucose control as well as lower levels of insulin-like growth factor 1.


Inclusion Criteria:

- Female

- Age 10-16 years

- Diagnosed with type 1 diabetes > 1 year (diabetic cohort)

Exclusion Criteria:

- BMI<5th percentile for age

- BMI>95th percentile for age

- Celiac disease

- Hyperthyroidism, uncontrolled hypothyroidism

- History of significant hepatic disease, renal disease, oncologic disease,
cardiovascular disease, psychiatric disease

- Anemia (Hgb <11)

- Taking medications other than insulin known to affect bone health (including hormonal
contraception, glucocorticoids, growth hormone)
We found this trial at
1
site
Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-2034
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mi
from
Boston, MA
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