Chronic Administration of Subcutaneous Brain Natriuretic Peptide (SQ BNP) on the Left Ventricular, Renal and Humoral Function and on the Integrated Response to Acute Sodium Loading
| Status: | Archived |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
To Define in Human Preclinical Diastolic Dysfunction (PDD) the Actions of Chronic Administration of SQ BNP on the Left Ventricular, Renal and Humoral Function and on the Integrated Response to Acute Sodium Loading - Protocol III
The purpose of this research study is to evaluate the effects of cardiac hormone replacement
with SQ (under the skin) injection of BNP (a hormone produced by the heart) on the pumping
ability of the heart, kidney function and levels of different hormones in the blood in
response to an intravenous salt solution.
Participants in this study will be randomized to receive BNP or placebo (an inactive, saline
shot). The participant will need to give themselves a shot in their stomach (similar to
diabetics giving themselves insulin) twice a day for twelve weeks. The study requires a
screening visit at the Charlton Building to determine eligibility and discuss the study. At
this visit a blood draw for heart and liver function and a six minute walk will be done.
There will also be two other outpatient visits and two inpatient stays, for 48 hours, in
the General Clinical Research Center (GCRC) at St. Marys Hospital. During the two stays in
the GCRC, blood and urine samples will be done to get heart and kidney function as well as
a research echo. After enrollment, the study lasts for twelve weeks.
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