EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 25 |
| Updated: | 4/6/2019 |
| Start Date: | April 2014 |
| End Date: | December 31, 2019 |
The purpose of the proposal is to identify new predictors of smoking progression in young
light smokers (YLS: 18-25 years & cpd < 5) using an 18-month longitudinal design and to
relate these predictors of progression to the genetic profile most highly associated with
smoking progression. A number of novel predictors will be assessed in 128 YLS. Predictors
will include individual differences (IDs) in EEG, reward sensitivity, attentional
performance, and mood during abstinence and in response to standardized and to self-selected
acute nicotine doses (ANIC), as well as genetically influenced affective traits, and smoking
history. The associations of a compelling genetic functional variant polymorphism,
rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking
progression and the novel predictors. The study is expected to provide insights into IDs in
mechanisms and predictors that contribute to smoking trajectories in YLS and thereby lead to
targeted pharmacotherapy and behavioral interventions for at-risk YLS.
light smokers (YLS: 18-25 years & cpd < 5) using an 18-month longitudinal design and to
relate these predictors of progression to the genetic profile most highly associated with
smoking progression. A number of novel predictors will be assessed in 128 YLS. Predictors
will include individual differences (IDs) in EEG, reward sensitivity, attentional
performance, and mood during abstinence and in response to standardized and to self-selected
acute nicotine doses (ANIC), as well as genetically influenced affective traits, and smoking
history. The associations of a compelling genetic functional variant polymorphism,
rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking
progression and the novel predictors. The study is expected to provide insights into IDs in
mechanisms and predictors that contribute to smoking trajectories in YLS and thereby lead to
targeted pharmacotherapy and behavioral interventions for at-risk YLS.
The purpose of the proposal is to identify new biobehavioral endophenotypes that predict
smoking progression in young light smokers (YLS: 18-25 years & cpd < 5) using an 18-month
longitudinal design and to relate these endophenotypes and progression to the genetic profile
most highly associated with smoking progression. A number of novel predictors will be
assessed in 128 YLS. Predictors will include individual differences (IDs) in EEG, reward
sensitivity, attentional performance, and mood during abstinence and in response to
standardized and to self-selected acute nicotine doses (ANIC), as well as genetically
influenced affective traits, and smoking history. The associations of a compelling genetic
functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will
also be related to smoking progression and the novel predictors. The study is expected to
provide insights into IDs in mechanisms and endophenotypes that contribute to smoking
trajectories in YLS and thereby lead to targeted pharmacotherapy and behavioral interventions
for at-risk YLS.
smoking progression in young light smokers (YLS: 18-25 years & cpd < 5) using an 18-month
longitudinal design and to relate these endophenotypes and progression to the genetic profile
most highly associated with smoking progression. A number of novel predictors will be
assessed in 128 YLS. Predictors will include individual differences (IDs) in EEG, reward
sensitivity, attentional performance, and mood during abstinence and in response to
standardized and to self-selected acute nicotine doses (ANIC), as well as genetically
influenced affective traits, and smoking history. The associations of a compelling genetic
functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will
also be related to smoking progression and the novel predictors. The study is expected to
provide insights into IDs in mechanisms and endophenotypes that contribute to smoking
trajectories in YLS and thereby lead to targeted pharmacotherapy and behavioral interventions
for at-risk YLS.
Inclusion Criteria:
- smokers of 3 to 30 cigarettes per week for past 6 months
Exclusion Criteria:
- Smoking fewer than 3 or more than 30 tobacco cigarettes per week
- Never smoked more than 30 cigarettes per week
- Psychoactive drug use other than caffeine or occasional marijuana
- Current serious psychiatric diagnosis (e.g., major depressive disorder)
- Recent drug dependence
- Left-handed
- Color blind
We found this trial at
1
site
Carbondale, Illinois 62901
Principal Investigator: David G Gilbert, PhD
Phone: 618-453-3527
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