Study of Blood Samples From Patients With Osteosarcoma
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | January 2009 |
Retrospective Study of Genetic Risk Factors for Osteosarcoma
This research trial studies blood samples from patients with osteosarcoma. Studying the
genes found in samples of blood from patients with osteosarcoma may help doctors identify
biomarkers related to the disease.
genes found in samples of blood from patients with osteosarcoma may help doctors identify
biomarkers related to the disease.
PRIMARY OBJECTIVE:
I. Conduct a large-scale candidate gene association study in osteosarcoma (OS) using cases
from the national Children's Oncology Group (COG) OS biology study (P9851 and successor
study AOST06B1).
SECONDARY OBJECTIVES:
I. Conduct a genome-wide association study (GWAS) of OS. II. Fine-map genomic regions
associated with OS to identify putative functional loci.
III. Conduct whole-exome sequencing of germline OS deoxyribonucleic acid (DNA) samples.
IV. Investigate the functional implications of promising genetic variants associated with
OS.
OUTLINE:
Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and
haplotypes to examine genetic variation, gene-gene interactions, and the population
structure.
I. Conduct a large-scale candidate gene association study in osteosarcoma (OS) using cases
from the national Children's Oncology Group (COG) OS biology study (P9851 and successor
study AOST06B1).
SECONDARY OBJECTIVES:
I. Conduct a genome-wide association study (GWAS) of OS. II. Fine-map genomic regions
associated with OS to identify putative functional loci.
III. Conduct whole-exome sequencing of germline OS deoxyribonucleic acid (DNA) samples.
IV. Investigate the functional implications of promising genetic variants associated with
OS.
OUTLINE:
Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and
haplotypes to examine genetic variation, gene-gene interactions, and the population
structure.
Inclusion Criteria:
- Blood samples collected from clinical trials COG-P9851 and COG-AOST06B1
We found this trial at
1
site
440 E Huntington Dr
Arcadia, California 91006
Arcadia, California 91006
(626) 447-0064
Principal Investigator: Sharon A. Savage, MD
Phone: 240-276-7241
Children's Oncology Group The Children's Oncology Group (COG), a National Cancer Institute supported clinical trials...
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