Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | November 2015 |
| End Date: | January 2017 |
A Double-Blind, Placebo-Controlled, Randomized, Parallel Group Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Opioid Analgesia Using the Oral Surgery Model of Acute Pain in Healthy Volunteers
Narcotics are widely used as the mainstay of pain treatment, although increasing doses are
required over time as the individual becomes tolerant to their effects. This can lead to the
development of dependence and abuse of these drugs. Research has identified a new way to
decrease the risk of developing tolerance to narcotics, by giving at the same time a drug
called rotigotine ("Neupro"). Rotigotine interferes with the body's chemical dopamine and is
FDA-approved for the management of Parkinson's Disease.
The purpose of this research study is to look at side effects and pain control in healthy
people after removal of wisdom teeth, which usually causes pain. It is thought that by
giving the study drug rotigotine with the narcotic pain reliever, there will be pain control
that will extend longer than when giving the narcotic alone.
required over time as the individual becomes tolerant to their effects. This can lead to the
development of dependence and abuse of these drugs. Research has identified a new way to
decrease the risk of developing tolerance to narcotics, by giving at the same time a drug
called rotigotine ("Neupro"). Rotigotine interferes with the body's chemical dopamine and is
FDA-approved for the management of Parkinson's Disease.
The purpose of this research study is to look at side effects and pain control in healthy
people after removal of wisdom teeth, which usually causes pain. It is thought that by
giving the study drug rotigotine with the narcotic pain reliever, there will be pain control
that will extend longer than when giving the narcotic alone.
Inclusion Criteria:
- Male and female patients aged 18 and over scheduled to undergo elective oral surgery
for the removal of impacted third molars
- Indicated for the removal of 3-4 third molars, at least two of which are categorized as
partial-boney or full-boney impactions
- Self-report of moderate or severe pain on a categorical scale with a minimum of 5 out
of 10 on the numerical rating scale following the offset of local anesthesia
Exclusion Criteria:
- History or intolerance to rotigotine
- Current or history of mental disorder or substance abuse
- Allergy or intolerance to opioids or local anesthetics
- Concurrent or recent use of agents that may confound the sedative effects of the study
drug (opioids, benzodiazepines) over the previous 7 days or alcohol ingestion in the
previous 24 hours
- Chronic or recent use of medications that might confound the effects of rotigotine,
e.g., antihistamines, prescription or over-the-counter NSAIDs (Nonsteroidal
anti-inflammatory drugs), acetaminophen, steroids, antidepressants, muscle relaxants.
- Concurrent or history of chronic diseases, e.g., diabetes, rheumatoid arthritis, liver
disease, cancer, hypertension or obesity (body mass index >35).
- Male and female patients aged 18 and over scheduled to undergo elective oral surgery
for the removal of impacted third molars
- Indicated for the removal of 3-4 third molars, at least two of which are categorized as
partial-boney or full-boney impactions
- Self-report of moderate or severe pain on a categorical scale with a minimum of 5 out
of 10 on the numerical rating scale following the offset of local anesthesia
Exclusion Criteria:
- History or intolerance to rotigotine
- Current or history of mental disorder or substance abuse
- Allergy or intolerance to opioids or local anesthetics
- Concurrent or recent use of agents that may confound the sedative effects of the study
drug (opioids, benzodiazepines) over the previous 7 days or alcohol ingestion in the
previous 24 hours
- Chronic or recent use of medications that might confound the effects of rotigotine,
e.g., antihistamines, prescription or over-the-counter NSAIDs (Nonsteroidal
anti-inflammatory drugs), acetaminophen, steroids, antidepressants, muscle relaxants.
- Concurrent or history of chronic diseases, e.g., diabetes, rheumatoid arthritis, liver
disease, cancer, hypertension or obesity (body mass index >35).
Inclusion Criteria:
- • Male and female patients aged 18 and over scheduled to undergo elective oral
surgery for the removal of impacted third molars
- Indicated for the removal of 3-4 third molars, at least two of which are
categorized as partial-boney or full-boney impactions
- Self-report of moderate or severe pain on a categorical scale with a minimum of
5 out of 10 on the numerical rating scale following the offset of local
anesthesia
Exclusion Criteria:
- History or intolerance to rotigotine
- Current or history of mental disorder or substance abuse
- Allergy or intolerance to opioids or local anesthetics
- Concurrent or recent use of agents that may confound the sedative effects of the
study drug (opioids, benzodiazepines) over the previous 7 days or alcohol
ingestion in the previous 24 hours
- Chronic or recent use of medications that might confound the effects of
rotigotine, e.g., antihistamines, prescription or over-the-counter NSAIDs,
acetaminophen, steroids, antidepressants, muscle relaxants.
- Concurrent or history of chronic diseases, e.g., diabetes, rheumatoid arthritis,
liver disease, cancer, hypertension or obesity (body mass index >35).
We found this trial at
1
site
Greenville, North Carolina 27834
Principal Investigator: Raymond Dionne, DDS, PhD
Phone: 252-744-2108
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