Vascular Reparative Mechanism in Diabetes
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Ocular, Diabetes |
| Therapuetic Areas: | Endocrinology, Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/20/2018 |
| Start Date: | October 30, 2011 |
| End Date: | June 30, 2020 |
Vascular Reparative Mechanism by ACE2/Ang-(1-7) in Diabetes
The purpose of this research study is to study blood stem cells in diabetic patients and
normal patients. We would like to better understand if these cells, called endothelial
precursor cells (EPCs), are not working as expected in people with diabetes. We would like to
see if the function of these cells can predict the development of diabetic retinopathy.
Diabetic retinopathy is an eye disease associated with diabetes in which the cells of the
retina are damaged. It can cause blurred vision, vision loss, blindness or possible bleeding
in the retina. Even with current treatments, the quality of life for people with diabetic
retinopathy is much reduced.
normal patients. We would like to better understand if these cells, called endothelial
precursor cells (EPCs), are not working as expected in people with diabetes. We would like to
see if the function of these cells can predict the development of diabetic retinopathy.
Diabetic retinopathy is an eye disease associated with diabetes in which the cells of the
retina are damaged. It can cause blurred vision, vision loss, blindness or possible bleeding
in the retina. Even with current treatments, the quality of life for people with diabetic
retinopathy is much reduced.
Inclusion Criteria:
- Men or women 18 years or older
- 39 type 1 or type 2 diabetic patients
- 13 with mild retinopathy
- 13 with moderate retinopathy
- 13 with severe, nonproliferative retinopathy
- 39 age and sex matched healthy controls
Exclusion Criteria:
- Current pregnancy as evidence by a urine pregnancy test as the blood from a pregnant
female will influence the results of the laboratory tests
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