Endothelin Receptor Function and Acute Stress
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 7/13/2018 |
| Start Date: | June 2015 |
| End Date: | April 2020 |
| Contact: | Ryan Harris, Ph.D. |
| Email: | ryharris@gru.edu |
| Phone: | 706-721-5998 |
Endothelin Receptor Function and Acute Stress (End-Stress)
Our bodies respond differently to stress. Animal studies by the investigators have found that
endothelin-1 plays a role in regulating blood pressure in response to stress. This study is
an extension of the investigators previous animal work to evaluate the role of endothelin-1
during stress in humans.
endothelin-1 plays a role in regulating blood pressure in response to stress. This study is
an extension of the investigators previous animal work to evaluate the role of endothelin-1
during stress in humans.
Using a salt sensitive animal model of prehypertension, the Dahl S rat,the investigators have
previously published that acute stress elicits a pressor response that is accompanied by an
increase in 8 isoprostane and endothelin-1. However, the pressor response is suppressed by
endothelin A/B receptor antagonism. Moreover, the investigators have identified that the
increase in 8-isoprostane occurs downstream of endothelin receptor activation. These data
indicate that endothelin receptor activation is a main player In the pressor response to
acute stress in pre-hypertensive animals; however, this phenomenon has yet to be elucidated
in humans.
previously published that acute stress elicits a pressor response that is accompanied by an
increase in 8 isoprostane and endothelin-1. However, the pressor response is suppressed by
endothelin A/B receptor antagonism. Moreover, the investigators have identified that the
increase in 8-isoprostane occurs downstream of endothelin receptor activation. These data
indicate that endothelin receptor activation is a main player In the pressor response to
acute stress in pre-hypertensive animals; however, this phenomenon has yet to be elucidated
in humans.
Inclusion Criteria:
- Men and premenopausal women (Ages 18-50 years old)
- Self-reported Black and White adults
- Lean adults (BMl <25 kg/m^)
- Obese adults (BMl > 30 kg/m^)
Exclusion Criteria:
- Having a BMI less than 16 kg/m2 (severely and very severely underweight) or that is
greater than 40 kg/m2 (Class III obesity)
- Having evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic
disease
- Having evidence of pregnancy
- Using medications that affect vascular tone (i.e., nitrates, etc.)
- Postmenopausal women
- Uncontrolled hypertension
- Individuals who are on a restricted salt diet
- Having a history of chronic pain
- Having a history of rheumatoid arthritis
- Using medications that are contraindicated with bosentan (i.e. glyburide,
cyclosporine)
- Liver dysfunction (which may be identified with the blood sample we take)
We found this trial at
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Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
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