Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies, Hospital, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2011 |
| End Date: | December 2016 |
| Contact: | Matthias Eikermann, MD, PhD |
| Email: | MEIKERMANN@PARTNERS.ORG |
| Phone: | 617-643-4408 |
Determining Predictors of Adequate Upper Airway Function in Ventilated Patients
This is part 2 of the #NCT01618240 under the same IRB protocol #2010P001919. The primary
objective of this study is to examine factors that are related to sleep-disordered breathing
and upper airway patency in critically ill patients who have been recently mechanically
ventilated. Our primary hypothesize is that sedatives and neuromuscular blocking agents
given in the ICU prior to extubation and during the first night following extubation are
associated with sleep-disordered breathing. The secondary hypotheses are that duration of
mechanical ventilation, BMI, and muscle strength are associated with sleep-disordered
breathing during the night after extubation.
The secondary objective is to evaluate if sleep-disordered breathing in the ICU can be
predicted by standard pulmonary function testing in the ICU.
objective of this study is to examine factors that are related to sleep-disordered breathing
and upper airway patency in critically ill patients who have been recently mechanically
ventilated. Our primary hypothesize is that sedatives and neuromuscular blocking agents
given in the ICU prior to extubation and during the first night following extubation are
associated with sleep-disordered breathing. The secondary hypotheses are that duration of
mechanical ventilation, BMI, and muscle strength are associated with sleep-disordered
breathing during the night after extubation.
The secondary objective is to evaluate if sleep-disordered breathing in the ICU can be
predicted by standard pulmonary function testing in the ICU.
Inclusion Criteria:
1. Patients admitted to the SICU
2. Age over 18 years.
3. Ventilated patients with an endotracheal tube for at least 24 hours.
Exclusion Criteria:
1. Decreased level of consciousness as defined by a Richmond Agitation Sedation Scale
(RASS) of 0.
2. Non-cooperative patient, CAM score positive for risk of delirium.
3. For women: pregnancy.
We found this trial at
1
site
185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Matthias Eikermann, MD, PhD
Phone: 617-643-4408
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