Observational Study of Biomarker During Liver Surgery



Status:Recruiting
Conditions:Liver Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 70
Updated:6/13/2018
Start Date:October 2014
End Date:December 2019
Contact:Jae-Sung Kim, PhD
Email:jae.kim@surgery.ufl.edu
Phone:352-392-7461

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Trial Summary
Trial Overview
Inclusion Criteria

Autophagy in Liver Injury: Changes in Autophagy Biomarkers During Liver Surgery

The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role
in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve
hepatic function of patients with liver diseases.

If asked to participate in this research study, it is because a liver resection/liver
transplantation surgery has been scheduled. During the procedure a small section will be
collected for additional testing of Sirtuin 1. In addition, information concerning the liver
disease, laboratory and pathology results after surgery will be collected by the
investigators.

Inclusion Criteria:

- liver resection > 2 segments,

- plate count > 100 x 109/L, and

- prothrombin activity >60%.

Exclusion Criteria:

- liver cirrhosis,

- portal hypertension,

- steatohepatitis or severe steatosis,

- patients receiving additional ablation therapies,

- laparoscopic resection, and

- simultaneous extrahepatic procedures such as colorectal resection or
pancreatoduodenectomy
We found this trial at
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UF Health
Gainesville, Florida 32608
Phone: 352-392-7461
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Gainesville, FL
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