A Study of Abemaciclib (LY2835219) In Participants With Previously Treated Breast Cancer That Has Spread



Status:Completed
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/7/2019
Start Date:June 10, 2014
End Date:October 22, 2018

Use our guide to learn which trials are right for you!

A Phase 2 Study of LY2835219 for Patients With Previously Treated Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer

The main purpose of this study is to evaluate whether the study drug known as abemaciclib is
effective in treating participants with breast cancer who have already tried other drug
treatments.


Inclusion Criteria.

- Have a diagnosis of Hormone Receptor Positive (HR+), Human Epidermal Growth Factor
Receptor 2 Negative (HER2-) breast cancer.

- Recurrent, locally advanced, unresectable or metastatic breast cancer with disease
progression following anti-estrogen therapy.

- Prior treatment with at least 2 chemotherapy regimens:

- At least 1 of these regimens must have been administered in the metastatic
setting.

- At least 1 of these regimens must have contained a taxane.

- No more than 2 prior chemotherapy regimens in the metastatic setting.

- Have a performance status (PS) of 0 to 1 on the Eastern Cooperative Oncology Group
scale.

- Have discontinued all previous therapies for cancer.

- Have the presence of measureable disease as defined by Response Evaluation Criteria in
Solid Tumors Version 1.1.

Exclusion Criteria:

- Have either a history of central nervous system (CNS) metastasis or evidence of CNS
metastasis on the magnetic resonance image of brain obtained at baseline.

- Received prior therapy with another cyclin-dependent kinases 4 and 6 (CDK4/6)
inhibitor.

- Have received treatment with a drug that has not received regulatory approval for any
indication within 14 or 21 days of the initial dose of study drug.

- Have had major surgery within 14 days of the initial dose of study drug.

- Have a history of any other cancer (except non-melanoma skin cancer or carcinoma
in-situ of the cervix).
We found this trial at
28
sites
Houston, Texas 77024
1349
mi
from 91732
Houston, TX
Click here to add this to my saved trials
3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
2203
mi
from 91732
Fort Myers, FL
Click here to add this to my saved trials
8940 N Kendall Dr # 300E
Miami, Florida 33176
2316
mi
from 91732
Miami, FL
Click here to add this to my saved trials
Austin, Texas 78731
1209
mi
from 91732
Austin, TX
Click here to add this to my saved trials
Bedford, Texas 76022
1203
mi
from 91732
Bedford, TX
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
2578
mi
from 91732
Boston, MA
Click here to add this to my saved trials
?
mi
from 91732
Brussel,
Click here to add this to my saved trials
5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
1887
mi
from 91732
Cincinnati, OH
Click here to add this to my saved trials
Columbia, Maryland 21044
2288
mi
from 91732
Columbia, MD
Click here to add this to my saved trials
Dallas, Texas 75231
1226
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1225
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado 80218
818
mi
from 91732
Denver, CO
Click here to add this to my saved trials
1195
mi
from 91732
Fort Worth, TX
Click here to add this to my saved trials
Minneapolis, Minnesota 55405
1508
mi
from 91732
Minneapolis, MN
Click here to add this to my saved trials
Nashville, Tennessee 37203
1762
mi
from 91732
Nashville, TN
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
2434
mi
from 91732
New York, NY
Click here to add this to my saved trials
Plano, Texas 75093
1222
mi
from 91732
Plano, TX
Click here to add this to my saved trials
Saint Petersburg, Florida 33705
2131
mi
from 91732
Saint Petersburg, FL
Click here to add this to my saved trials
San Francisco, California 94143
356
mi
from 91732
San Francisco, CA
Click here to add this to my saved trials
Santa Barbara, California 93105
99
mi
from 91732
Santa Barbara, CA
Click here to add this to my saved trials
357
mi
from 91732
Sedona, AZ
Click here to add this to my saved trials
Sherman, Texas 75090
1227
mi
from 91732
Sherman, TX
Click here to add this to my saved trials
The Woodlands, Texas 77380
1344
mi
from 91732
The Woodlands, TX
Click here to add this to my saved trials
Tucson, Arizona 85712
430
mi
from 91732
Tucson, AZ
Click here to add this to my saved trials
429
mi
from 91732
Tucson, AZ
Click here to add this to my saved trials
Tyler, Texas 75702
1315
mi
from 91732
Tyler, TX
Click here to add this to my saved trials
Vancouver, Washington 98684
832
mi
from 91732
Vancouver, WA
Click here to add this to my saved trials
110 Irving St NW
Washington, District of Columbia 20010
(202) 877-7000
Washington Hosp Ctr MedStar Washington Hospital Center is a not-for-profit, 926-bed, major teaching and research...
2281
mi
from 91732
Washington,
Click here to add this to my saved trials