Probing the Cannabinoid System in Individuals With a Family History of Psychosis



Status:Recruiting
Conditions:Schizophrenia, Psychiatric, Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 55
Updated:6/8/2018
Start Date:January 2014
End Date:April 2019
Contact:Christina Luddy, BS
Email:christina.luddy@yale.edu
Phone:203-932-5711

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The overall purpose of this study is to determine whether a family history of psychosis is
associated with an altered cannabinoid system. This will be tested by studying individuals
with and without a family history of psychosis and comparing their responses to delta
9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that
compared to controls with no family history of psychoses, individuals with a family history
of psychoses will have an altered response to THC.


Inclusion Criteria FHP:

- Exposure to cannabis at least once in their lifetime

- Medically and psychiatrically healthy based on screening

- Having one relative with a confirmed psychotic disorder

Exclusion Criteria FHP:

- Current or lifetime major DSM-IV Axis I disorder

- Current or lifetime treatment (at least 6 months) with psychotropic medications for
major psychiatric or neurological illness

- Major or unstable medical illness that might impact safety of the subject in the study

- Cannabis naive

- IQ less than 85

- Less than a high school diploma or its educational equivalent

- Pregnancy or lactation

- Major current or recent (<6 weeks) psychosocial stressors.

Inclusion Criteria FHN :

- Exposure to cannabis at least once in their lifetime

- Medically and psychiatrically healthy based on screening

Exclusion Criteria FHN:

- Having a family member with psychosis

- Current or lifetime major DSM-IV Axis I disorder

- Current or lifetime treatment (at least 6 months) with psychotropic medications for
major psychiatric or neurological illness

- Major or unstable medical illness that might impact safety of the subject in the study

- Cannabis naive

- IQ less than 85

- Less than a high school diploma or its educational equivalent

- Pregnancy or lactation

- Major current or recent (<6 weeks) psychosocial stressors.
We found this trial at
1
site
950 Campbell Ave
West Haven, Connecticut 06516
(203) 932-5711
Principal Investigator: Mohini Ranganathan, MD
Phone: 203-932-5711
VA Connecticut Healthcare System VA Connecticut encompasses an inpatient facility and Ambulatory Care Center in...
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from
West Haven, CT
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