Strength Training and Endurance Exercise for LIFE
| Status: | Recruiting |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 1/11/2019 |
| Start Date: | September 15, 2014 |
| End Date: | September 30, 2019 |
| Contact: | Kris Ann K Oursler, MD |
| Email: | KrisAnn.Oursler@va.gov |
| Phone: | (540) 982-2463 |
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
Research is needed to determine safe and effective exercise rehabilitation programs to
prevent and improve physical disability in older adults living with HIV. This problem is of
great importance to the VA. The majority of the 25 thousand HIV-infected veterans are over 50
years of age (64%). The combined effect of aging and inflammation increase the risk for
physical disability in older HIV-infected veterans. This translational exercise training
trial will examine the cardiac and skeletal muscle effects of combined aerobic exercise and
resistance training to attenuate the functional declines of aging with HIV by reducing the
deleterious consequences of chronic inflammation. Findings will guide future rehabilitation
research on cardiac remodeling and inflammation of skeletal muscle. The proposed research
will advance the goal to develop effective rehabilitation strategies that improve the health
of older HIV-infected veterans.
prevent and improve physical disability in older adults living with HIV. This problem is of
great importance to the VA. The majority of the 25 thousand HIV-infected veterans are over 50
years of age (64%). The combined effect of aging and inflammation increase the risk for
physical disability in older HIV-infected veterans. This translational exercise training
trial will examine the cardiac and skeletal muscle effects of combined aerobic exercise and
resistance training to attenuate the functional declines of aging with HIV by reducing the
deleterious consequences of chronic inflammation. Findings will guide future rehabilitation
research on cardiac remodeling and inflammation of skeletal muscle. The proposed research
will advance the goal to develop effective rehabilitation strategies that improve the health
of older HIV-infected veterans.
The objective of this study is to determine the effect of exercise training on the central
(cardiovascular) and peripheral (muscular) impairments underlying poor physical function by
comparing older HIV-infected veterans randomized to combine aerobic and resistance exercise
training versus usual care. The study hypothesis is that a progressive aerobic and resistance
rehabilitation program will increase aerobic capacity and muscle strength, which will be
mediated by improved diastolic function, increased muscle mass, and decreased systemic
inflammation. To test this hypothesis, investigators will conduct a randomized 16-week trial
of progressive aerobic and resistance training versus usual care control in 40 sedentary
older (50+ years) HIV-infected veterans. The study will determine the effects of exercise
training on aerobic capacity and diastolic function, and their relationship to changes in
biomarkers of systemic inflammation and cardiac fibrosis (AIM 1). The study will also
determine the effect of exercise training on strength and muscle mass, and their relationship
to changes in biomarkers of systemic inflammation (AIM 2).
(cardiovascular) and peripheral (muscular) impairments underlying poor physical function by
comparing older HIV-infected veterans randomized to combine aerobic and resistance exercise
training versus usual care. The study hypothesis is that a progressive aerobic and resistance
rehabilitation program will increase aerobic capacity and muscle strength, which will be
mediated by improved diastolic function, increased muscle mass, and decreased systemic
inflammation. To test this hypothesis, investigators will conduct a randomized 16-week trial
of progressive aerobic and resistance training versus usual care control in 40 sedentary
older (50+ years) HIV-infected veterans. The study will determine the effects of exercise
training on aerobic capacity and diastolic function, and their relationship to changes in
biomarkers of systemic inflammation and cardiac fibrosis (AIM 1). The study will also
determine the effect of exercise training on strength and muscle mass, and their relationship
to changes in biomarkers of systemic inflammation (AIM 2).
Inclusion Criteria:
- HIV-infected veterans adult 50 years of age and older under medical care for HIV
- Antiretroviral Therapy
Exclusion Criteria:
- Patients with comorbid conditions that could have a potential impact on their ability
to perform exercise testing and training will be excluded according to the American
College of Sports Medicine
- Only sedentary adults will be eligible. Individuals that participate in regular
structured aerobic exercise or resistance training in the prior 6-months will be
excluded
We found this trial at
2
sites
Salem, Virginia 24153
Principal Investigator: Kris Ann K Oursler, MD
Phone: 540-982-2463
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Baltimore, Maryland 21201
Phone: 410-605-7851
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