Chlorthalidone and HCTZ Impacts on Platelet Activation
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2014 |
| End Date: | December 2016 |
| Contact: | Sandy Byers, RN |
| Email: | sandrabyers@creighton.edu |
| Phone: | 402-280-4961 |
Evaluation of Platelet Effects of Chlorthalidone and Hydrochlorothiazide
This will be a randomized, double-blinded, three-period crossover study of platelet
activation and aggregation in 30 non-smoking healthy volunteers comparing chlorthalidone
(CTD), hydrochlorothiazide (HCTZ), and aspirin (ASA; active control). The study hypothesis
is that CTD has different effects on platelet activation and aggregation than HCTZ.
activation and aggregation in 30 non-smoking healthy volunteers comparing chlorthalidone
(CTD), hydrochlorothiazide (HCTZ), and aspirin (ASA; active control). The study hypothesis
is that CTD has different effects on platelet activation and aggregation than HCTZ.
Inclusion Criteria:
- Men or women age 19 or older
- Not currently taking any routinely scheduled prescription or over the counter
medications or herbal supplements
- No use of aspirin, clopidogrel, prasugrel, ticagrelor, cilostazol, dipyridamole,
NSAID medications, or herbal supplements within the previous 7 days and able to
refrain from use during the study period
- Systolic blood pressure > 110 mmHg and diastolic blood pressure > 60 mmHg
- Non-smoker
Exclusion Criteria:
- Previous adverse reaction or allergy to HCTZ, CTD, or ASA
- Severe sulfonamide hypersensitivity (anaphylaxis or Stevens-Johnson syndrome)
- Diagnosis of any chronic disease or condition
- History of gout or hyperuricemia
- History of pancreatitis
- History of systemic lupus erythematosus (SLE)
- History of hypokalemia requiring treatment
- Pregnant or planning to become pregnant during the study period
- Breastfeeding
- History of hypotension
- History of gastrointestinal bleeding
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