Effect of Aging on Bariatric Surgery-induced Changes in Metabolism and Cognition



Status:Recruiting
Conditions:Cognitive Studies, Endocrine
Therapuetic Areas:Endocrinology, Psychiatry / Psychology
Healthy:No
Age Range:21 - 80
Updated:4/17/2018
Start Date:April 2014
End Date:April 2019
Contact:Andrew Suzo
Email:Andrew.Suzo@osumc.edu
Phone:614-293-9964

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The investigators hypothesize that the improvements in insulin sensitivity, beta (β)-cell
function, and inflammation will be greater, and the improvement in sarcopenic obesity will be
less, in younger versus older individuals after substantial weight loss induced by sleeve
gastrectomy bariatric surgery.

With an aging population that is increasingly susceptible to obesity and obesity-related
comorbidities including sarcopenia and diabetes, effective and safe treatment options
tailored to the needs of older adults are imperative. While medication and lifestyle
interventions generally fail to achieve sustained large-scale weight loss, bariatric surgery
is the most effective long-term weight loss treatment for obese patients and improves many of
the medical complications associated with obesity. Sleeve gastrectomy (SG) results in
substantial weight loss and may be more appropriate for older adults due to its low rate of
complications and mortality. Therefore, SG has been proposed as a reasonable primary
treatment modality in older obese individuals, with a substantial recent increase in the
number of interventions performed. Despite the potential benefits, very little is known of
the physiologic and metabolic effects of bariatric surgery, including SG, on glucose
homeostasis and muscle physiology in older adults. A fundamental understanding of the effects
of excess adiposity and weight loss interventions is of profound importance, especially with
emerging evidence that earlier treatment of obesity may delay/prevent many comorbidities. An
underlying inflammatory state has been implicated in the pathogenesis of sarcopenia and
insulin resistance and may provide an important connection to the age-related declines seen
in older obese patients. Therefore, this study aims to evaluate the modifying effect of age
and inflammation on the SG-induced changes in body composition, muscle physiology, and
insulin sensitivity. This protocol will be conducted in two age cohorts (greater than 60 and
less than 50 years old).

Inclusion Criteria:

- Age 21-80 yrs old

- BMI ≥ 35 kg/m2

- Undergoing laparoscopic sleeve gastrectomy (SG)

Exclusion Criteria:

- Smokers

- Presence of diabetes mellitus

- Taking any medication that might affect metabolism

- Severe organ dysfunction

- Pregnant or breastfeeding

- Prior gastrointestinal surgery that might affect study results

- Unable or unwilling to follow the study protocol or any reason the research team
believes the subject is not an appropriate candidate for this study

- Weight >450 pounds (Will be unable to fit on the DXA scanner)
We found this trial at
1
site
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Principal Investigator: David Bradley, MD, MS
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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