Exercise for Depressed Smokers



Status:Recruiting
Conditions:Smoking Cessation
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 65
Updated:4/6/2019
Start Date:February 2014
End Date:July 2019
Contact:Ana M. Abrantes, Ph.D.
Email:ana_abrantes@brown.edu
Phone:401-455-6440

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Aerobic Exercise for Smokers With Depressive Symptomatology

The purpose of this study is to test the effect of a moderate-intensity aerobic exercise
intervention for helping individuals with elevated depressive symptoms to quit smoking. The
investigators expect that this project will contribute much needed knowledge about the role
that aerobic exercise can play in smoking cessation. The long-term goal of this program of
research is to disseminate an effective, aerobic exercise (AE) intervention for smoking
cessation that can be readily adopted by smokers with elevated depressive symptoms, including
those with current major depressive disorder (MDD).


Inclusion Criteria:

1. are between 18 and 65 years of age

2. are current smokers (i.e., smoking at least 10 cigarettes per day)

3. have currently elevated depressive symptoms (CES-D ≥ 6)

4. are sedentary, i.e., have not participated regularly in aerobic exercise (for at least
90 minutes per week during the past three months)

Exclusion Criteria:

1. DSM-IV diagnosis of current mania

2. DSM-IV diagnosis of bipolar rapid cycling

3. lifetime history of psychotic disorder or DSM-IV diagnosis of current psychotic
symptoms

4. DSM-IV diagnosis of current substance abuse or dependence in the past 6 months

5. DSM-IV diagnosis of anorexia or bulimia nervosa

6. current suicidality or homicidality

7. marked organic impairment

8. current use of antidepressant medication for less than 3 months or change in
antidepressant medication or dosage in the past 3 months,

9. physical disabilities or medical problems that would prevent or hinder participation
in a program of moderate intensity exercise (i.e., physician denied medical clearance)

10. current pregnancy or intent to become pregnant during the next 12 weeks

11. contraindications for use of the nicotine patch (e.g., pregnancy, recent myocardial
infarction, arrhythmia, angina, untreated hypertension, untreated diabetes, and
previous adverse reaction to the patch)

12. current illness or medications that may alter proposed inflammatory markers (e.g.,
acute infection, immune disorders, aspirin)

13. current use of any pharmacotherapy or other treatment for smoking cessation.
We found this trial at
1
site
345 Blackstone Blvd
Providence, Rhode Island 02906
(401) 455-6200
Principal Investigator: Ana M. Abrantes, Ph.D.
Butler Hospital Founded in 1844, Butler Hospital is the state's only non-profit, free-standing psychiatric hospital...
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mi
from
Providence, RI
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