Utility of PharmacoGenomics for Reducing Adverse Drug Effects



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:April 2014
End Date:July 2017
Contact:Study Coordinator
Email:upgrade@companiondxlab.com

Use our guide to learn which trials are right for you!

UPGRADE aims to see whether data from Pharmacogenomic Testing (PGx) can help physicians
manage patient medication regimens and assess if the testing has an effect on reducing
adverse drug reactions, hospitalizations and emergency department visits.

The way an individual processes a drug is in part determined by their genes, and there is
known to be genetic variation between humans in the way drugs are metabolized. The study of
the way genes affect a person's response to drugs is known as "Pharmacogenomics."


Inclusion Criteria:

- Subject plans to undergo current index PGx testing at the time of enrollment or
underwent current index PGx testing within the prior 1-year period, for genes known
to influence metabolism of at least one target drug

- Subject is aged ≥18 years

- Subject is able and willing to provide written informed consent

- Subject reveals a history of at least one TDAE or an inadequate therapeutic effect
from a target drug over the 12-month period preceding expected receipt of PGx test
results

- Subject is not taking an investigational medication or in an interventional trial
that would interfere with participation in the registry

Exclusion Criteria:

- Subject is currently hospitalized

- Subject's medical and medication history is unavailable over the 90-day periods
preceding and following the receipt of pharmacogenomic test results

- Subject is unable to provide an accurate history due to mental incapacity

- Subject is known to have undergone prior pharmacogenomic testing (exclusive of the
current index PGx testing) for genes specific to the target drugs within the 2-year
period preceding enrollment and these results have been previously evaluated
We found this trial at
41
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Lincoln, Nebraska 68510
Phone: 402-817-2235
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3801 N. Fairfax Drive
Arlington, Virginia 22203
703-527-8100
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Allentown, Pennsylvania 18101
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Arcadia, California 91007
Phone: 626-574-0188
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Asheboro, North Carolina 27203
Phone: 336-625-1360
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Asheville, North Carolina 28803
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Augusta, Arkansas 72006
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Austin, Texas 78744
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Boca Raton, Florida 33432
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Chicago, Illinois 60611
Phone: 312-763-2211
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Clearwater, Florida 33765
Phone: 727-447-3000
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Covington, Louisiana 70433
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Dunmore, Pennsylvania 18512
Phone: 570-961-8000
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El Cajon, California 92020
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Elkton, Maryland 21921
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Hilliard, Ohio 43026
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Jacksonville, Florida 32216
Phone: 904-493-3333
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3535 Southern Blvd
Kettering, Ohio 45429
(937) 298-4331
Phone: 937-643-9939
Kettering Medical Center Our flagship hospital, Kettering Medical Center, stands proudly in Kettering, Ohio. From...
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Lake Charles, Louisiana 70601
Phone: 337-292-0885
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Lake Clarke Shores, Florida 33406
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League City, Texas 77573
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McAllen, Texas 78501
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Miami, Florida 33137
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Miami Lakes, Florida 33014
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Millburn, New Jersey 07041
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Montville, New Jersey 07045
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Moorestown, New Jersey 08057
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Newark, Delaware 19711
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Olympia Fields, Illinois 60461
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Palm Bay, Florida 32905
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Pharr, Texas 78577
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Phillipsburg, New Jersey 08865
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Sayre, Pennsylvania 18840
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Scottsdale, Arizona 85251
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Shaker Heights, Ohio 44120
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Shippensburg, Pennsylvania 17257
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South Chesterfield, Virginia 23803
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Trenton, New Jersey 08638
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Waco, Texas 76710
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Willow Grove, Pennsylvania 19090
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