ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases



Status:Completed
Conditions:Breast Cancer, Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/30/2017
Start Date:April 2014
End Date:September 2017

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A Phase II, Open-Label, Multi-Center Study of ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases

This is a Phase 2 study to see if an investigational drug, ANG1005, can shrink tumor cells in
breast cancer patients with recurrent brain metastases.


Inclusion Criteria:

1. ≥ 18 years old

2. Breast cancer

3. Recurrent brain metastases from breast cancer

4. At least one radiologically-confirmed and measurable metastatic brain lesion ( ≥ 0.5
cm)

5. Neurologically stable

6. Karnofsky Performance Status (KPS) score ≥ 70

Exclusion Criteria:

1. Prior treatment with ANG1005/GRN1005

2. Pregnancy or lactation

3. Inadequate bone marrow reserve

4. Any evidence of severe or uncontrolled diseases

5. Patients with the presence of an infection including abscess or fistulae, or known
infection with hepatitis B or C or HIV

6. CNS disease requiring immediate neurosurgery intervention (e.g., resection, shunt
placement, etc.)

7. Known allergy to paclitaxel or any of its components
We found this trial at
19
sites
3855 Health Sciences Dr,
La Jolla, California 92093
(858) 822-6100
UC San Diego Moores Cancer Center Established in 1978, UC San Diego Moores Cancer Center...
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La Jolla, CA
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Chapel Hill, North Carolina 27599
(919) 962-2211
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
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Chapel Hill, NC
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Cleveland, OH
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Albuquerque, New Mexico 87131
(505) 277-0111
University of New Mexico Founded in 1889 as New Mexico’s flagship institution, the University of...
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Albuquerque, NM
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Augusta, GA
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Aurora, Colorado 80045
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Aurora, CO
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22 South Greene Street
Baltimore, Maryland 21201
410-328-7904
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
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Baltimore, MD
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Bethesda, Maryland
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Bethesda, MD
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303 East Superior Street
Chicago, Illinois 60611
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Chicago, IL
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Commack, NY
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Grand Rapids, MI
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Houston, Texas 77030
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Houston, TX
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Los Angeles, California 90033
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Los Angeles, CA
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Los Angeles, CA
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Orange, CA
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Pittsburgh, Pennsylvania 15213
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Pittsburgh, PA
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Pittsburgh, Pennsylvania 15232
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Pittsburgh, PA
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San Antonio, TX
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Tucson, Arizona 85724
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Tucson, AZ
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