A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:8/5/2018
Start Date:June 4, 2014
End Date:September 13, 2016

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A Phase 1 Study To Evaluate The Safety, Tolerability, Immunogenicity, Pharmacokinetics And Pharmacodynamics Of Multiple Ascending Doses Of Pf-06342674 (rn168) In Adults With Type 1 Diabetes

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and
immunogenicity of multiple doses of PF-06342674. Several dose levels will be evaluated.


Inclusion Criteria:

- Women and men age 18 and older.

- Diagnosis of type 1 diabetes within 2 years of randomization.

- Peak stimulated C-peptide levels ≥ 0.15 ng/mL.

Exclusion Criteria:

- Anticipated ongoing use of diabetes medications other than insulin.

- Evidence or history of diabetic complications with significant end-organ damage.

- Episode of severe hypoglycemia within 60 days of randomization.

- Multiple hospitalizations for diabetic ketoacidosis.
We found this trial at
21
sites
Minneapolis, Minnesota 55455
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Atlanta, Georgia 30309
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Atlanta, GA
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Aurora, Colorado 80010
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Aurora, CO
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Chicago, Illinois 60637
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Chicago, IL
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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Chicago, IL
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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Durham, North Carolina 27710
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Durham, NC
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Durham, NC
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Minneapolis, MN
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New Haven, CT
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333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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New Haven, CT
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New Haven, Connecticut 06520
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New Haven, CT
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Saint Louis, Missouri 63110
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Saint Louis, MO
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4921 Parkview Place
Saint Louis, Missouri 63110
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Saint Louis, MO
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Saint Louis, Missouri 63110
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Saint Louis, MO
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San Diego, CA
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San Diego, CA
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San Francisco, California 94143
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San Francisco, CA
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Worcester, Massachusetts 01605
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Worcester, MA
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55 N Lake Ave
Worcester, Massachusetts 01655
(508) 856-8989
Univ of Massachusetts Med School As the commonwealth's only public medical school, we take seriously...
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Worcester, MA
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