Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy

This is a prospective study to determine if the adjuvant use of Curcumin improves
recurrence-free survival in patients after radical prostatectomy compared to placebo

Inclusion Criteria:

- radical prostatectomy for adenocarcinoma of prostate

- pathologically confirmed T1-T3 disease

- no sign of lymph node or metastatic disease

- Eastern Cooperative Oncology Group(ECOG) status 0-2

- adequate renal and liver function

- no plan to receive adjuvant hormone or radiation therapy

- life expectancy of 3 years

Exclusion Criteria:

- must not have exceeded 3 months from time of surgery to enrollment into study

- T3b or T4 or node positive disease

- hormone therapy before surgery

- history of gallbladder problems or gallstones, or biliary obstruction

- radiation therapy as primary treatment after surgery

- antiplatelet or anticoagulant agents

- history of gastric or duodenal ulcers or hyperacidity syndromes