Increasing Motivation for Antiretroviral Therapy Initiation: A Pilot Intervention

Many persons with HIV refuse recommended treatment or delay initiation of antiretroviral
therapy (ART). Widespread belief in conspiracy theories regarding the origin and treatment
of HIV may complicate the ART decision-making process. Research has found that conspiracy
beliefs and mistrust in the mainstream medical system are common among African-Americans
attending an HIV primary care clinic and that conspiracy beliefs are more likely to be held
by patients who are not on ART. Moreover, research shows that conspiracy beliefs and other
maladaptive cognitions predict subsequent readiness to begin ART. The investigators have
developed an intervention called PATCH: Personal Approaches to Treatment Choices for HIV.
PATCH is a brief intervention designed to support participants' decision-making processes
and enhance intrinsic motivation to initiate ART, using motivational interviewing (MI)
techniques. The intervention targets HIV-positive African-American adults in inner-city
Baltimore, Maryland who are suboptimally engaged in care and who endorse conspiracy beliefs
about HIV or low readiness to begin ART.

In this project the investigators will conduct a small randomized controlled pilot trial to
test the potential efficacy of PATCH in producing positive attitudinal changes, including a
reduction in conspiracy beliefs and perceived barriers to ART and an increase in stated
readiness to begin ART. The investigators will compare PATCH to an attentional control.
Participants will be recruited from outpatient HIV clinics settings but will be individuals
who are not taking ART. Assessments will be conducted at baseline, post-treatment (estimated
4-8 weeks post-baseline), and at 3-month post-baseline follow-up. The specific aims are: (1)
Develop and refine a manual for a brief MI intervention to support ART decision-making and
reduce the likelihood of ART refusal: (2) Evaluate the feasibility and acceptability of
implementing the PATCH intervention in a small sample of individuals who are
African-American, recommended for ART but who are not current taking it, and who experience
multiple barriers to ART adherence; and (3) Conduct a small randomized controlled pilot to
test the potential efficacy of the PATCH intervention in producing positive attitudinal
changes, including a reduction in conspiracy beliefs and perceived barriers to ART and
stated readiness to begin ART.

Inclusion Criteria:

- Known to the recruitment site to be HIV-positive

- African-American or multiracial with African-American heritage.

- Able to speak and understand English.

- At least one of the following:

1. Sub-optimally involved in HIV care (defined as no regular source of HIV primary
care, clinically eligible for ART but not taking it, or received an offer of ART
in the last year but not currently taking it.

2. Non-adherent to ART (defined as being offered ART but not taking it or not
appropriately adhering to it (as reflected by a score of 10 or less on screening
questionnaire) at the time of enrollment.

3. Conspiracy beliefs (defined as a score of 10 or more on screening questionnaire
or states that would not be ready to take ART if recommended).

Exclusion Criteria:

- Known diagnosis of mental retardation or dementia.

- Active psychosis or suicidality evident in initial interview.