Oxytocin in Opiate Dependence: A Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence



Status:Recruiting
Conditions:Psychiatric, Gastrointestinal
Therapuetic Areas:Gastroenterology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:4/2/2016
Start Date:January 2013
Contact:Nick Schaffner
Phone:619-543-6999

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Oxytocin in Opiate Dependence: A Double-blind, Within-subjects, Placebo-controlled Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence

Opiate dependence is a serious problem, and oxytocin has many properties which make it
attractive as a treatment for this type of substance dependence. This experiment will test
the effects of oxytocin on a variety of brain-based processes in patients with opiate
dependence. The investigators hypothesize that intranasal oxytocin in these conditions will
enhance emotional processing and will have beneficial effects on stress responses in
opiate-dependent patients.


Inclusion Criteria:

- adult men 18 years or older

- meet DSM-IV criteria for opiate dependence, and no other active substance dependence
disorder save nicotine dependence

- clinically stable, and low risk for suicide as determined by principal investigator
and screening questionnaire

- abstinent from non-prescribed opiate use for at least two weeks from Baseline 1 and
free from opiate withdrawal symptoms. If on agonist therapy, dose must be stable for
2 weeks before study visit.

- must be able to use nasal spray

- negative salivary drug screen, save for opiates

Exclusion Criteria:

- any active medical condition that in the opinion of the investigator will interfere
with the objectives of the study

- any active, severe mental illness, neurological disorder, including schizophrenia,
autism, Asperger's syndrome

- are unsuitable in any way to participate in this study, in the opinion of the
investigator

- hospitalizations due to complications of an Axis 1 disorder for the past 12 months,
excluding drug or alcohol rehabilitation

- any clinically significant chronic pain condition, as determined by the principal
investigator

- positive salivary drug screen at the time of the visit, for any substance other than
opiates or another prescribed medication
We found this trial at
1
site
34800 Bob Wilson Drive
San Diego, California 92103
?
mi
from
San Diego, CA
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