Phase 1 Study of Topical Ocular PAN-90806 for Neovascular AMD

Inclusion Criteria:

- Diagnosis in the study eye of active, pathologic, newly diagnosed and previously
untreated, subfoveal choroidal neovascular (CNV) lesions secondary to neovascular AMD

- Aged 50 years or older

- Demonstrate the ability, or have a family member who is willing and able, to instill
topical ocular drops in the study eye

Exclusion Criteria:

- No prior ocular or systemic treatment or surgery for neovascular AMD in the study eye

- History of or current clinical evidence in the study eye of:

- aphakia

- diabetic macular edema

- any ocular inflammation or infections

- pathological myopia

- retinal detachment

- advanced glaucoma

- significant media opacity, including cataract

- History or evidence of the following surgeries in the study eye:

- penetrating keratoplasty or vitrectomy;

- corneal transplant;

- corneal or intraocular surgery within 3 months of Screening

- Uncontrolled hypertension despite use of antihypertensive medications

- Participation in any investigational drug or device study, systemic or ocular, within
past 3 months

- Women who are pregnant or nursing

- Known serious allergies or hypersensitivity to the fluorescein dye used in
angiography or to the components of the PAN-90806 formulation