Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia

PRIMARY OBJECTIVES:

I. Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961
and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia.

II. Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi
anemia patients using western blot techniques.

OUTLINE:

Previously collected cryopreserved cells are analyzed via western blot to identify patients
with Fanconi anemia.

Inclusion Criteria:

- Treated on COG-2961 or COG-AAML03P1

- At high risk of having Fanconi anemia, defined as meeting one the following groups of
clinical criteria:

- Group 1: Prolonged neutropenia after induction, severe regimen-related toxicity
(mucositis, veno-occlusive disease, end-organ damage)

- Group 2: Early non-relapse death (induction, consolidation)

- Group 3: Small-for-weight, secondary malignancies