Ocular Surface Immune Response in Dry Eye Disease
| Status: | Completed |
|---|---|
| Conditions: | Ocular, Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/20/2017 |
| Start Date: | January 2014 |
| End Date: | July 2015 |
Ocular Surface Immune Response in Dry Eye Disease: Analysis of Conjunctival and Peripheral Corneal Immune Cell Alterations by In Vivo Confocal Microscopy and Clinical Correlation
In vivo confocal microscopy (IVCM) is a sensitive imaging tool for detecting dry
eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an
in vivo metric to measure inflammatory changes in the central cornea. The objective of the
current study is to assess inflammatory response changes in the peripheral cornea and the
conjunctiva by analyzing epithelial immune cell density and morphology in these areas and
then correlating the IVCM findings to clinical signs and symptoms to establish novel
objective imaging biomarkers.
eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an
in vivo metric to measure inflammatory changes in the central cornea. The objective of the
current study is to assess inflammatory response changes in the peripheral cornea and the
conjunctiva by analyzing epithelial immune cell density and morphology in these areas and
then correlating the IVCM findings to clinical signs and symptoms to establish novel
objective imaging biomarkers.
For Dry Eye Disease Participants
Inclusion Criteria:
- Age >18
- Ability to consent to study
- Symptoms of dry eye disease for at least 6 months, such foreign body sensation,
burning, stinging, light sensitivity
- Positive vital dye staining of the cornea
- At least one of the following objective signs: (Schirmer I <10 mm at 5 minutes),
decreased (<0.2 mm) tear meniscus, decreased tear breakup time (TBUT) of <10 seconds,
positive vital dye staining of the conjunctiva
For Age-Match Controls
Inclusion Criteria:
- Between the ages of 18-89
- The ability to provide informed consent for study inclusion
- Clear, healthy cornea
- Normal tear meniscus (> 0.3 mm)
For Dry Eye Disease Participants
Exclusion Criteria:
- History of contact lens wear in the past 3 months
- History of ocular surgery in the past 6 months
- Active ocular allergies
- History of ocular infection in the past 3 months
- History of diabetes
- History of topical or systemic anti-inflammatory therapy in the past 1 month
For Age-Match Controls
Exclusion Criteria:
- History of ocular or eyelid surgery within the past 12 months
- History of herpetic or other infectious keratitis or other inflammatory eye disease
- History of any other acute ocular disease
- Current use of topical medications (not including artificial tears)
- Current use of contact lenses
- History of ocular carcinoma or any recent ocular topical chemotherapy or radiotherapy
- History of cancer elsewhere in the body which is currently under systemic chemotherapy
- Current glaucoma disease requiring use of glaucoma drops
- History of Diabetes mellitus
- Current diagnosis of dry eye disease
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