Pivotal Response Treatment Package for Young Children With Autism

Researchers at the Stanford University School of Medicine are seeking participants for a
research study examining the effectiveness of a pivotal response treatment package (PRT-P) in
targeting language skills in young children with autism. Research has demonstrated that
behavioral interventions, such as Pivotal Response Training (PRT), lead to improvements in
the core symptoms of autism. Researchers have begun to develop strategies to investigate the
effectiveness of combining a parent training program teaching parents how to implement PRT
with in-home, therapist-implemented treatment. To determine the effectiveness of a PRT-P, it
will be compared to a delayed treatment group (DTG) by conducting a randomized controlled
24-week trial. This research will allow us to help in the development of therapeutic
approaches that can meet the increasing service demands for families. We hope that
investigating interventions that aim to improve core deficits will aid clinicians in
providing better care for children with autism.

Inclusion Criteria:

- Diagnosis of Autism Spectrum Disorder (ASD) based on Autism Diagnostic Interview-
Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS-2), and expert clinical
opinion

- Males and females in good medical health between 2.0 and 5.11 years

- Ability to participate in the testing procedures to the extent that valid standard
scores can be obtained

- Language delay as measured by the Preschool Language Scale: Standard score at least 1
Standard Deviation below average for expressive language ability

- Stable treatment, speech therapy, school placement, psychotropic medication(s) or
biomedical intervention(s) for at least 1 month prior to baseline measurements with no
anticipated changes during study participation

- No more than 60 minutes of individual 1:1 speech therapy per week

- Availability of at least one parent who can consistently participate in parent
training and research measures

- Parents intend on continuing Pivotal Response Treatment Package (PRT-P) for a minimum
of 12 weeks

- Parents must be 18 years of age or older

Exclusion Criteria:

- Current or lifetime diagnosis of severe psychiatric disorder, such as bipolar disorder

- Receiving in-home Applied Behavior Analysis (ABA) of 10 hours or more

- A genetic abnormality, such as Fragile X

- Presence of active medical problem, such as unstable seizure disorder or heart disease

- Previous adequate PRT trial

- Participants living more than 50 miles from Stanford University

- At least one room of the house must be available to be dedicated to treatment during
session times

- There must be no serious health and safety risks present in the home environment

- The research team has the right to refuse to perform sessions in-home even if the
criteria above are met