Ph2a Study to Evaluate IW-3718 in Patients With Gastroesophageal Reflux Not Completely Responsive to Proton Pump Inhibitors

Inclusion Criteria:

- Patient is between 18 and 65 years of age at the Screening Visit; females must not be
pregnant or must not be breastfeeding;

- Patient has a confirmed diagnosis of gastroesophageal reflux disease, must be
currently taking a proton pump inhibitor (PPI), and must be experiencing GERD
symptoms as specified by the protocol.

Exclusion Criteria:

- Patient may not meet any of the excluded conditions specified in the protocol;

- Patient is experiencing alarm symptoms such as GI bleeding, anemia, vomiting,
dysphagia, or unexpected weight loss;

- Patient has a clinically significant hypersensitivity or allergies to any of the
active ingredients or excipients in the study medication.