Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis
| Status: | Completed |
|---|---|
| Conditions: | Bronchitis |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/27/2019 |
| Start Date: | December 2013 |
| End Date: | December 2014 |
A Randomized Trial of Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in The Emergency Department
This is a randomized, double-blind, controlled trial in the Pediatric Emergency Department.
The primary objective is to determine whether nebulized 3% hypertonic saline is more
effective than nebulized 0.9% saline in the treatment of bronchiolitis in the emergency
department.
The primary objective is to determine whether nebulized 3% hypertonic saline is more
effective than nebulized 0.9% saline in the treatment of bronchiolitis in the emergency
department.
Inclusion Criteria:
- Children 2-12 months of age presenting to Emergency Department
- Patients with a diagnosis of bronchiolitis defined as the first episode of wheezing
and/or crackles in a child younger than 12 months who has physical findings of a viral
respiratory infection and has no other explanation for the wheezing and/or crackles
- Patients with an RDAI score ≥ 6 as measured by a trained respiratory therapist
Exclusion Criteria:
- Previous history of wheezing
- Known heart or lung disease
- Premature birth defined as birth before 37 weeks gestation
- Immunosuppression or immunodeficiency
- Treatment with corticosteroids in the previous 48 hours
- Critically ill children - progressive respiratory failure requiring higher level of
care, vital signs instability/need for emergency interventions to prevent clinical
deterioration
- Oxygen saturation <85% on room air at the time of recruitment
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