LDE225 for Patients With PTCH1 or SMO Mutated Tumors
Status: | Completed |
---|---|
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 4/21/2016 |
Start Date: | February 2014 |
End Date: | March 2015 |
Modular Phase II Study to Link Targeted Therapy to Patients With Pathway Activated Tumors: Module - 5 LDE225 for Patients With PTCH1 or SMO Mutated Tumors
The purpose of this signal seeking study is to determine whether treatment with LDE225
demonstrates sufficient efficacy in hedgehog pathway-mutated solid tumors and/or hematologic
malignancies to warrant further study
demonstrates sufficient efficacy in hedgehog pathway-mutated solid tumors and/or hematologic
malignancies to warrant further study
Inclusion Criteria:
- Patient has confirmed diagnosis of a select solid tumor (except medulloblastoma,
basal cell carcinoma and pancreatic adenocarcinoma) or hematological malignancy
(except CML, ALL and AML).
- Patient has pre-identified tumor with a PTCH1 or SMO mutation.
- Patient has received at least one prior treatment for recurrent, metastatic and /or
locally advanced disease and for whom no standard therapy options are anticipated to
result in a durable remission.
- Patient has progressive and measurable disease as per RECIST 1.1. or other
appropriate hematological guidelines.
- Patient has an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
Exclusion Criteria:
- Patients has received prior treatment with LDE225.
- Patients has neuromuscular disorders associated with elevated CK (i.e. inflammatory
myopathies, muscular dystrophy, amyotrophic lateral sclerosis and spinal muscular
atrophy) or are on concomitant treatment with drugs that are recognized to cause
rhabdomyolysis
- Patients has primary CNS tumor or CNS tumor involvement
- Patient has received chemotherapy or anticancer therapy ≤ 4 weeks prior to starting
study drug
We found this trial at
10
sites
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