Very Low Nicotine Cigarettes in Smokers With Schizophrenia
| Status: | Completed |
|---|---|
| Conditions: | Schizophrenia, Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/17/2018 |
| Start Date: | November 17, 2014 |
| End Date: | August 31, 2017 |
Smokers with serious mental illness including those with schizophrenia and bipolar disorder
infrequently attempt and attain sustained smoking abstinence and have a 25-year shorter
lifespan due to smoking-related illness. This study will examine whether reducing the
nicotine content of cigarettes to non-addicting levels is a viable method of reducing smoking
in smokers with serious mental illness. Smokers will be randomized to one of two experimental
conditions: 1) very low nicotine content (VLNC) cigarettes or 2) normal nicotine content
(NNC) cigarettes. Participants will be assessed for patterns of tobacco use, biomarkers of
exposure, subjective responses (e.g., satisfaction, craving, withdrawal symptoms),
psychiatric symptoms, cognitive performance, smoking cue reactivity and smoking topography.
infrequently attempt and attain sustained smoking abstinence and have a 25-year shorter
lifespan due to smoking-related illness. This study will examine whether reducing the
nicotine content of cigarettes to non-addicting levels is a viable method of reducing smoking
in smokers with serious mental illness. Smokers will be randomized to one of two experimental
conditions: 1) very low nicotine content (VLNC) cigarettes or 2) normal nicotine content
(NNC) cigarettes. Participants will be assessed for patterns of tobacco use, biomarkers of
exposure, subjective responses (e.g., satisfaction, craving, withdrawal symptoms),
psychiatric symptoms, cognitive performance, smoking cue reactivity and smoking topography.
Inclusion Criteria:
- Age 18-70
- Schizophrenia, schizoaffective disorder or bipolar disorder
- Smoke an average of at least 10 cigarettes per day for at least 1 year
- Breath carbon monoxide (CO) levels >8 ppm (if ≤ 8 ppm, then nicotine (NicAlert) Strip
> 2)
Exclusion Criteria:
- Pregnant or nursing
- Seeking treatment for smoking
- Medical contraindications
We found this trial at
1
site
69 Brown Street
Providence, Rhode Island 02912
Providence, Rhode Island 02912
(401) 863-1000
Principal Investigator: Jennifer Tidey, Ph.D.
Brown University Located in historic Providence, Rhode Island and founded in 1764, Brown University is...
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