Safety and Immunogenicity Study of Prophylactic Streptococcus Pneumoniae Vaccine
| Status: | Completed |
|---|---|
| Conditions: | Pneumonia |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 4/21/2016 |
| Start Date: | November 2013 |
| End Date: | February 2015 |
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability, and Immunogenicity of GEN-004, a Streptococcus Pneumoniae Protein Subunit Vaccine, in Adult Subjects
GEN-004 is a combination of 3 conserved proteins from Streptococcus pneumoniae. This is a
randomized, double-blind, placebo-controlled, dose escalation study. Eligible subjects (male
and non-pregnant female) will be assigned sequentially to 1 of 3 dose cohorts and randomized
in a 3:1:1 ratio to receive GEN-004 with adjuvant, GEN-004 without adjuvant, or placebo,
respectively. Each subject will receive up to 3 doses at 4 week intervals.
Subjects will be followed for safety, tolerability, and immunogenicity for 12 months after
their last dose.
randomized, double-blind, placebo-controlled, dose escalation study. Eligible subjects (male
and non-pregnant female) will be assigned sequentially to 1 of 3 dose cohorts and randomized
in a 3:1:1 ratio to receive GEN-004 with adjuvant, GEN-004 without adjuvant, or placebo,
respectively. Each subject will receive up to 3 doses at 4 week intervals.
Subjects will be followed for safety, tolerability, and immunogenicity for 12 months after
their last dose.
Inclusion Criteria:
1. Males and non-pregnant females, ages 18 to 55 years inclusive.
2. Willing and able to provide written informed consent.
3. Willing to perform and comply with all study procedures including attending clinic
visits as scheduled.
4. Willing to practice adequate contraception that may include, but is not limited to,
abstinence, monogamous relationship with vasectomized partner, vasectomy, barrier
methods such as condoms, diaphragms, intrauterine devices, and licensed hormonal
methods for 28 days before and 90 days after receiving Study Drug.
Exclusion Criteria:
1. Immunocompromised individuals, including those receiving immunosuppressive doses of
corticosteroids (more than 20 mg of prednisone given daily or on alternative days for
2 weeks or more within 6 months prior to the first dose of Study Drug, any dose of
corticosteroids within 30 days of the first dose of Study Drug, or high dose inhaled
corticosteroids [> 960 µg/day of beclomethasone dipropionate or equivalent]) or other
immunosuppressive agents.
2. Presence or history of autoimmune disease, regardless of current treatment.
3. Insulin dependent diabetes.
4. Positive serologic test for HIV-1 or hepatitis C infection; positive hepatitis B
surface antigen (HBsAg).
5. Screening serum chemistry or hematology abnormality ≥ Grade 1.
6. Screening urinalysis abnormality ≥ Grade 2.
7. Positive urine drug screen or alcohol Breathalyzer test at Screening or on Study Day
1.
8. Other active, uncontrolled co-morbidities that, in the opinion of the Investigator
would make the subject unsuitable for the study or unable to comply with the study
requirements.
NOTE: Subjects who are taking a medication to control an underlying co-morbidity may
be enrolled if there have been no changes to their medication within 60 days prior to
the first dose of Study Drug.
9. Any acute illness including, fever (>100.4 degrees F [> 38 degrees C]) within 3 days
prior to the first dose of Study Drug.
10. Pregnant or nursing women.
11. Receipt of any investigational drug within 30 days prior to the first dose of Study
Drug.
12. Receipt of blood products within 90 days prior to the first dose of Study Drug.
13. Donation of blood or plasma within 56 days prior to Screening.
14. Receipt of a live vaccine within 28 days prior or a subunit vaccine within 14 days
prior to the first dose of Study Drug or planned vaccination within 30 days following
the last dose of Study Drug.
15. Prior vaccination with pneumococcal vaccine.
16. History of hypersensitivity to any component of the vaccine or history of an allergic
reaction to an immunization.
17. History of invasive pneumococcal disease (i.e., sepsis, meningitis or pneumonia with
bacteremia).
18. History of drug or alcohol abuse that, in the opinion of the Investigator, would
interfere with the subject's ability to comply with the study requirements.
19. Any other condition that, in the opinion of the Investigator would make the subject
unsuitable for the study or unable to comply with the study requirements.
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