Lymphocyte Profiles and Activation Status in Patients With Graft-Versus-Host Disease



Status:Not yet recruiting
Conditions:Cancer, Blood Cancer, Orthopedic, Hematology
Therapuetic Areas:Hematology, Oncology, Orthopedics / Podiatry
Healthy:No
Age Range:Any
Updated:2/8/2015
Start Date:November 2013

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Lymphocyte Profiles and Activation Status in the Development of Chronic Graft-versus-Host Disease

This research trial studies lymphocyte profiles and activation status in patients with
graft-versus-host disease. Studying samples of blood in the laboratory from patients with
cancer may help doctors identify and learn more about biomarkers related to
graft-versus-host disease.

PRIMARY OBJECTIVES:

I. To explore and assess changes in subsets and activation status of B-, T,-, and natural
killer (NK) lymphocytes in peripheral blood following allogeneic stem cell transplant and
how they may be associated with clinical events with an ultimate future goal of conducting a
larger successor study to identify potential therapeutic targets based on its findings.

SECONDARY OBJECTIVES:

I. To assess the feasibility of obtaining and comparing patients with chronic
graft-versus-host disease (cGVHD) with time-matched stem cell transplant (SCT) patients
without cGVHD and identify logistical challenges with obtaining and processing samples in
each of the subgroups of interest for these analyses.

II. To assess and explore differences in lymphocyte subsets (B-, T-, and NK) between those
with vs. without cGVHD.

III. To assess and explore differences in cytokines in patients with cGVHD vs. those
without.

IV. To describe lymphocyte subsets and activation and explore how these may be related to
specific clinical manifestations of cGVHD.

OUTLINE:

Blood samples are analyzed for activation status of B lymphocytes, T lymphocytes, and NK
lymphocytes via flow cytometry, enzyme-linked immunosorbent assay (ELISA), enzyme-linked
immunosorbent spot (ELISPOT), immunoblot, and microarray assays.

Inclusion Criteria:

- Allogeneic SCT groups: Patients who have received stem cell transplantation at The
Ohio State University are eligible and who are at or beyond day +75 following
allogeneic SCT regardless of previous diagnosis of acute or chronic graft-versus-host
disease (GVHD)

- Autologous SCT group: Patients who have received an autologous stem cell transplant
at The Ohio State University and who have achieved platelet and neutrophil
engraftment
We found this trial at
1
site
300 W 10th Ave
Columbus, Ohio 43210
(800) 293-5066
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center...
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mi
from
Columbus, OH
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