Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease



Status:Recruiting
Conditions:Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:50 - 85
Updated:5/12/2016
Start Date:November 2013
Contact:Darren P Casey, Ph.D.
Email:darren-casey@uiowa.edu
Phone:319-384-1009

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The overarching question addressed in the current project is: Does dietary nitrate
supplementation (8 weeks) improve physiological function in patients with peripheral
arterial disease (PAD)? The investigators will specifically address whether dietary nitrate
supplementation enhances blood vessel function, blood pressure regulation, and exercise
capacity. The proposed project uses an array of clearly defined measurements which will
allow investigators to quantify blood vessel function (vasodilator responsiveness and
arterial stiffness), blood pressure (variability and responsiveness to stress), and
functional capacity before and after 8 weeks of dietary supplementation.


Inclusion Criteria:

- Documented peripheral artery disease

- Ankle-Brachial Index (ABI) < or = to 0.90

Exclusion Criteria:

- Non-atherosclerotic vascular disease

- Critical limb ischemia

- Active ischemic ulceration

- Recent (within one year) revascularization

- Symptomatic coronary artery disease (angina pectoris)

- Heart failure

- Resting systolic blood pressure > 180 mmHg or diastolic pressure > 100 mmHg

- Hypotension (resting systolic BP < 90 mmHg)

- Smoking or history of smoking within past one year

- Use of phosphodiesterase V inhibitor drugs

- Women with history of hormone replacement therapy within the past 6 months
We found this trial at
1
site
101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
University of Iowa With just over 30,000 students, the University of Iowa is one of...
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