Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)



Status:Recruiting
Conditions:Cardiology, Anemia
Therapuetic Areas:Cardiology / Vascular Diseases, Hematology
Healthy:No
Age Range:12 - 21
Updated:10/21/2017
Start Date:October 2013
End Date:December 2016

Use our guide to learn which trials are right for you!

A Randomized, Controlled, Double Blinded Clinical Trial of Intravenous Iron Sucrose in Adolescents With Non-anemic Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)

This study is designed to investigate whether the treatment of non-anemic iron deficiency
with intervenous iron sucrose will result in decreased symptom reporting and improved
cardiovascular indices in adolescents (age 12-21) with Postural Orthostatic Tachycardia
Syndrome (POTS).


Inclusion criteria

- aged 12-21 years

- chronic (>3 months)symptoms of orthostatic intolerance (including but not limited to
lightheadedness, syncope, headache, fatigue, weakness, sweating, nausea and
palpitations)

- symptomatic orthostatic heart rate increase of greater than or equal to 40 beats per
minute during a 10 minute 70 degree head up tilt study

- presence of non-anemic iron deficiency, defined as serum ferritin level less than or
equal to 20 ug/L with normal hemoglobin

Exclusion criteria

- orthostatic hypotension within 3 minutes of 70 degree head up tilt

- pregnant or lactating females

- presence of other organ failure or systemic illness that can affect autonomic function

- concurrent medication therapy with anticholinergic, alpha-adrenergic antagonists,
beta-adrenergic antagonists unless medication is held for five half-lives prior to
study

- laboratory evidence of anemia or iron overload

- personal history of hematochromatosis or first degree relative with hematochromatosis

- known sensitivity to Venofer (TM) or other intravenous iron preparations
We found this trial at
1
site
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Phone: 507-284-4462
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
?
mi
from
Rochester, MN
Click here to add this to my saved trials