Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients



Status:Completed
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:November 2013
End Date:August 2014

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A Multicenter, Randomized, Double-blind, Parallel Group Study to Assess the Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients Comparing Two Titration Regimens

The purpose of this study is to assess the safety and tolerability of initiating LCZ696 in
heart failure patients with reduced ejection fraction (HF-rEF) using conservative (reaching
target dose over 6 weeks) and condensed (reaching target dose over 3 weeks) up-titration
regimens.


Inclusion Criteria:

- Age ≥ 18 years; CHF with New York Heart Association class II-IV; left ventricular
ejection fraction ≤ 35%; on beta blockers

Exclusion Criteria:

- Potassium > 5.2 mmol/l; estimated glomerular filtration rate < 30 ml/min/1.73 m2;
systolic blood pressure <100 mmHg or > 180 mmHg; history of intolerance to
recommended target doses of angiotensin converting enzyme inhibitors or angiotensin
receptor blockers

Other protocol-defined inclusion/exclusion criteria may apply.
We found this trial at
25
sites
Livingston, Texas 77351
1363
mi
from 91732
Livingston, TX
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Anaheim, California 92801
16
mi
from 91732
Anaheim, CA
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Anchorage, Alaska 99508
2343
mi
from 91732
Anchorage, AK
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Atlantis, Florida 33462
2305
mi
from 91732
Atlantis, FL
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Aurora, Illinois 60504
1698
mi
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Aurora, IL
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Buffalo, New York 14215
2184
mi
from 91732
Buffalo, NY
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Chiefland, Florida 32626
2078
mi
from 91732
Chiefland, FL
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Dallas, Texas 75216
1225
mi
from 91732
Dallas, TX
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Evansville, Indiana 47713
1715
mi
from 91732
Evansville, IN
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6637
mi
from 91732
Gabrovo,
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Gilbert, Arizona 85234
363
mi
from 91732
Gilbert, AZ
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Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Laurelton, New York 11422
2446
mi
from 91732
Laurelton, NY
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Marion, Ohio 43302
1955
mi
from 91732
Marion, OH
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Minneapolis, Minnesota 55402
1509
mi
from 91732
Minneapolis, MN
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Oak Ridge, Tennessee 37830
1903
mi
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Oak Ridge, TN
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Peoria, Illinois 61615
1616
mi
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Peoria, IL
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Slidell, Louisiana 70458
1666
mi
from 91732
Slidell, LA
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St. Louis, Missouri 63110
1570
mi
from 91732
St. Louis, MO
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Tacoma, Washington 98405
939
mi
from 91732
Tacoma, WA
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Torrance, California 90502
22
mi
from 91732
Torrance, CA
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Tucson, Arizona 85745
417
mi
from 91732
Tucson, AZ
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