The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature
| Status: | Withdrawn |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 5 - 11 |
| Updated: | 8/19/2018 |
| Start Date: | January 2013 |
| End Date: | December 2014 |
The purpose of the study is to evaluate the predictive value of IGF-1 generation test for
growth velocity during GH treatment for 12 months.
growth velocity during GH treatment for 12 months.
Inclusion Criteria:
- ability to provide written informed consent
- Prepubertal males and females form 5- 11years old
- Bone age <11 years in males and <9 years in females
- Height SD score<-2.25SD in males and females
- IGF-1SD score <-1SD in both males and females
- Peak GH level after stimulation >10ng/ml
Exclusion Criteria:
- History of prior chemotherapy and or radiation
- Active neoplasm
- Pediatric patients with closed epiphyses
- Prader-Willi syndrome, Turner syndrome or any other genetic or chromosomal anomaly
- Treatment with inhaled or systemic steroids
- BMI <5th percentile or >95th percentile
- Tanner 2 at clinical or biochemical examination by ultrasensitive LH and FSH
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