A Phase 2 Multicenter Randomized Clinical Trial of CNTF for MacTel



Status:Completed
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:21 - 80
Updated:9/14/2018
Start Date:April 2014
End Date:May 22, 2017

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A Phase 2 Multicenter Randomized Clinical Trial of Ciliary Neurotrophic Factor (CNTF) for Macular Telangiectasia Type 2 (MacTel)

This study is a phase 2, randomized, multi-center, single-masked study to evaluate the
efficacy and safety of the NT-501 implants in participants with Mactel.


Inclusion Criteria:

- Participant must be offered sufficient opportunity to review and to understand the
informed consent form, agree to the form's contents and sign the protocol's informed
consent

- Participant must have at least one study eye with a positive diagnosis of MacTel Type
2

- Participant must have an IS/OS PR break in the study eye(s) and en face ellipsoid zone
(area of IS/OS loss) as measured by SDOCT between 0.16 mm2 and 4.00 mm2

- If female, participant must be incapable of pregnancy

- If male, participant must agree to use an effective form of birth control during the
study

Exclusion Criteria:

- Participant is unable to provide informed consent

- Participant is less than 21 years of age or greater than 80 years of age

- Participant is medically unable to comply with study procedures or follow-up visits

- Participant was a study subject in any other clinical trial of an intervention (drug
or device) within the last 6 months

- Participant is pregnant or breastfeeding
We found this trial at
9
sites
Sydney, New South Wales
7514
mi
from 91732
Sydney,
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
1919
mi
from 91732
Atlanta, GA
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100 Stein Plaza
Los Angeles, California 90095
13
mi
from 91732
Los Angeles, CA
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Ann Arbor, Michigan 48105
1931
mi
from 91732
Ann Arbor, MI
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Beachwood, Ohio 44122
2042
mi
from 91732
Beachwood, OH
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Bethesda, Maryland 20892
2277
mi
from 91732
Bethesda, MD
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2578
mi
from 91732
Boston, MA
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Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
1654
mi
from 91732
Madison, WI
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Miami, Florida 33136
2320
mi
from 91732
Miami, FL
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