Pivotal Response Treatment for Children With Autism Spectrum Disorders

Conditions:Neurology, Psychiatric, Psychiatric, Autism
Therapuetic Areas:Neurology, Psychiatry / Psychology
Age Range:4 - 35
Start Date:May 2012
End Date:May 2018
Contact:Jiedi Lei
Phone:203 737 4378

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The purpose of this study is to evaluate the application of an evidence-based, manualized
treatment for children with Autism Spectrum Disorder (ASD) (Pivotal Response Treatment, PRT)
to children ages four through six years of age with ASD. Specifically, children will be
randomly assigned to receive either (1) 10 hours per week of intervention services, including
two hours per week of parent education, and eight hours per week of direct
clinician-delivered services, or (2) a treatment as usual control. Intervention will focus on
enhancing the following developmental skills: expressive and receptive language, play, and
social interaction. Outcome measures will address changes in the aforementioned domains
during structured observation and standardized assessment.

Inclusion Criteria:

- Inclusion Criteria:

Participants will:

1. Fit the age requirement: age 4-35

2. Have been diagnosed previously with an ASD and meet criteria for ASD when
characterized by research team.

3. Be in good medical health

4. Be cooperative with testing

5. English is a language spoken in the family

6. Successfully complete an fMRI and EEG scan

7. Full-scale IQ>50

Exclusion Criteria:

- Exclusion Criteria:

Participants may not have:

1. Any metal or electromagnetic implants, including:

1. Cardiac pacemaker

2. Defibrillator

3. Artificial heart valve

4. Aneurysm clip

5. Cochlear implants

6. Shrapnel

7. Neurostimulators

8. History of metal fragments in eyes or skin

2. Significant hearing loss or other severe sensory impairment

3. A fragile health status.

4. Current use of prescription medications that may affect cognitive processes under

5. A history of significant head trauma or serious brain or psychiatric illness
We found this trial at
New Haven, Connecticut 06512
Principal Investigator: Kevin Pelphrey, Ph.D
New Haven, CT
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