Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Psoriasis |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Rheumatology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2013 |
| End Date: | April 2016 |
A Phase 3, Randomized, Double-blind, Placebo-controlled Study Of The Efficacy And Safety Of 2 Doses Of Tofacitinib (Cp-690,550) In Subjects With Active Psoriatic Arthritis And An Inadequate Response To At Least One Tnf Inhibitor
To examine the safety and efficacy of tofacitinib in subjects with active psoriatic
arthritis who have previously had an inadequate response to at least one TNF inhibitor
either due to lack of efficacy or an adverse event.
arthritis who have previously had an inadequate response to at least one TNF inhibitor
either due to lack of efficacy or an adverse event.
Inclusion Criteria:
- Active arthritis at screening/baseline as indicated by >/= 3 tender/painful and 3
swollen joints
- Active plaque psoriasis at screening
- Inadequate efficacy or lack of toleration to previously administered TNF inhibitor
Exclusion Criteria:
- Non-plaque forms of psoriasis (with exception of nail psoriasis)
- History of autoimmune rheumatic disease other than PsA; also prior history of or
current, rheumatic inflammatory disease other than PsA
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