Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors



Status:Completed
Conditions:Arthritis, Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:August 2013
End Date:April 2016

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A Phase 3, Randomized, Double-blind, Placebo-controlled Study Of The Efficacy And Safety Of 2 Doses Of Tofacitinib (Cp-690,550) In Subjects With Active Psoriatic Arthritis And An Inadequate Response To At Least One Tnf Inhibitor

To examine the safety and efficacy of tofacitinib in subjects with active psoriatic
arthritis who have previously had an inadequate response to at least one TNF inhibitor
either due to lack of efficacy or an adverse event.


Inclusion Criteria:

- Active arthritis at screening/baseline as indicated by >/= 3 tender/painful and 3
swollen joints

- Active plaque psoriasis at screening

- Inadequate efficacy or lack of toleration to previously administered TNF inhibitor

Exclusion Criteria:

- Non-plaque forms of psoriasis (with exception of nail psoriasis)

- History of autoimmune rheumatic disease other than PsA; also prior history of or
current, rheumatic inflammatory disease other than PsA
We found this trial at
41
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Bethlehem, Pennsylvania 18015
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Birmingham, Alabama 35205
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Camperdown,
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Charleston, South Carolina 29406
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Corpus Christi, Texas 78404
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Covina, California 91723
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Duncansville, Pennsylvania 16635
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Eagan, Minnesota 55121
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Fullerton, CA
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Hagerstown, Maryland 21740
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Houston, Texas 77098
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Indianapolis, Indiana 46214
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Jackson, Tennessee 38305
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Lebanon, New Hampshire 03756
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Lexington, Kentucky 40504
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Lincoln, Nebraska 68512
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Middleburg Heights, Ohio 44130
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Salt Lake City, Utah 84132
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San Diego, California 92108
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St. Louis, Missouri 63117
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Trumbull, Connecticut 06611
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Worcester, Massachusetts 01610
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Zephyrhills, Florida 33542
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